| Type | Description |
|---|---|
| Definition | membrane metallo endopeptidase |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:29:00 | Study identified neutral endopeptidase (NEP) that is upregulated in human abdominal aortic aneurysm (AAA) tissue as a major enzyme that metabolizes and inactivates APLN17 peptide. NEP cleavage resistant APLN17 analog ameliorated Ang II-mediated adverse aortic remodeling and AAA formation in mouse model of AAA. Study defines a critical role of APLN in AAA formation through induction of ACE2 and protection of vascular SMCs. | 31189595 |
| 2020-03-21 10:37:00 | Results suggest that although the expression of MME in the mouse is dysregulated after injury in a NRG1 dependent manner it does not appear to modulate the rate of nerve repair. It does, however, appear to have a role in moderating excessive responses to noxious stimuli. | 31339187 |
| 2019-08-03 12:11:00 | Following low-fat feeding, NEP(-/-) mice exhibited lower beta- and alpha-cell mass compared with wild-type controls. A high-fat diet had no effect on these parameters in wild-type mice, but in NEP(-/-) mice, it resulted in the expansion of beta-cell mass. | 29553871 |
| 2018-06-02 12:02:00 | feeding monohydroxylated demethoxycurcumin (also named demethylcurcumin) or dihydroxylated bisdemethoxycurcumin (also named bisdemethylcurcumin) to APPswe/PS1dE9 double transgenic mice upregulated NEP levels in the brain and reduced Abeta accumulation in the hippocampus and cortex. | 27407064 |
| 2018-05-05 11:58:00 | The abundance of elastic fibers was reduced and fragmented in obesity, suggesting that the reduction in elastic fibers is initially caused by increased neprilysin and decreased fibrillin-1 expression, which may inhibit formation and stabilization of elastic fibers, resulting in skin fragility in obesity. | 27892729 |
| Type | IDs |
|---|---|
| Synonymous | 6030454K05Rik, C85356, CALLA, CD10, NEP, SFE |
| Gene |
UniProtKB-ID:
NEP_MOUSE
UniprotKB:
Q61391
UniParc:
UPI0000022CE8
EMBL:
AK033824,
M81591,
AK031446,
BC034092,
BC066840
Ensembl:
ENSMUSG00000027820
KO:
mmu:17380
|
| Nucleutide sequences |
EMBL-CDS:
BAC27410.1,
AAH66840.1,
AAA37386.1,
AAH34092.1,
BAC28487.1
Ensembl_TRS:
ENSMUST00000029400,
ENSMUST00000194150,
ENSMUST00000194134
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029400,
ENSMUSP00000141544,
ENSMUSP00000142205
RefSeq:
XP_006501161.1,
NP_001344264.1,
NP_032630.2,
NP_001276391.1,
NP_001276392.1
|
| Others |
UniRef100:
UniRef100_Q61391
UniRef90:
UniRef90_P08473
UniRef50:
UniRef50_P08473
UniGene:
Mm.296022
CCDS:
CCDS17381.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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