| Type | Description |
|---|---|
| Definition | AF4/FMR2 family, member 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-16 11:57:00 | These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia. | 28394257 |
| 2015-02-07 11:47:00 | define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs | 25282333 |
| 2011-12-17 11:40:00 | Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1. | 21896721 |
| 2010-01-25 12:00:00 | small changes in the levels of a single transcriptional cofactor AF4 can deleteriously affect normal cerebellum function and opens new avenues of research for the manipulation of the IGF-1 pathway in the treatment of cerebellar ataxia in humans. | 20007461 |
| 2010-01-21 00:00:00 | demonstrated that Af4 is specifically expressed in Purkinje cells; hypothesize that the expression of mutant Af4 leads to neurodegeneration | 12629167 |
| Type | IDs |
|---|---|
| Synonymous | 9630032B01Rik, AW319193, Af4, Mllt2h, Rob |
| Gene |
UniProtKB-ID:
Q3UP77_MOUSE,
E9Q921_MOUSE,
Q3UQD9_MOUSE,
A3KMF4_MOUSE
UniprotKB:
Q3UP77,
E9Q921,
Q3UQD9,
A3KMF4
UniParc:
UPI0000EE05BD,
UPI00005AC22A,
UPI00005AC14D,
UPI00001C350B
EMBL:
AL731554,
AK143742,
AL713989,
AK142554,
BC131665
Ensembl:
ENSMUSG00000029313
KO:
mmu:17355
|
| Nucleutide sequences |
EMBL-CDS:
BAE25520.1,
BAE25103.1,
AAI31666.1
Ensembl_TRS:
ENSMUST00000031256,
ENSMUST00000054979
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000031256,
ENSMUSP00000059744
RefSeq:
XP_006534864.1,
NP_001074267.1,
XP_036020739.1,
NP_598680.3
|
| Others |
UniRef100:
UniRef100_Q3UQD9,
UniRef100_E9Q921,
UniRef100_A3KMF4,
UniRef100_Q3UP77
UniRef90:
UniRef90_Q3UP77,
UniRef90_Q3UQD9,
UniRef90_O88573
UniRef50:
UniRef50_Q3UQD9,
UniRef50_Q3UP77,
UniRef50_O88573
UniGene:
Mm.6949
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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