| Type | Description |
|---|---|
| Definition | major intrinsic protein of lens fiber |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 14:08:00 | Lenses expressing only C-terminally end-cleaved aquaporin-0 show loss of transparency. | 30826060 |
| 2019-08-17 11:15:00 | A specific distribution profile of intact and end-cleaved AQP0 from the outer cortex to the inner nucleus is required in the lens for establishing refractive index gradient to enable proper focusing without aberrations and for maintaining transparency. | 30821811 |
| 2019-05-25 10:04:00 | positively charged amino acids in the AQP0 extracellular loop domains interact with the negatively charged lipids in the plasma membrane to promote cell-to-cell adhesion for compaction of fiber cells. | 30348525 |
| 2017-09-30 10:31:00 | Cataractogenesis in Mip(Nat) mutants are caused by defects in MIP expression. | 28442635 |
| 2017-06-03 11:39:00 | These data suggest that while relatively few genes ( approximately 1.5% of the transcriptome) were differentially regulated >2-fold in the Mip-/- lens, calpain hyper-activation acts as a terminal pathogenic event during lens fiber cell death and cataract formation. | 27524245 |
| Type | IDs |
|---|---|
| Synonymous | Aqp0, Cat, Cts, Hfi, Lop, MIP26, MP26, Svl, shrivelled |
| Gene |
UniProtKB-ID:
MIP_MOUSE
UniprotKB:
P51180
UniParc:
UPI00000225F9
EMBL:
AK136287,
AK053494,
U27502,
AK053490,
AF000143
Ensembl:
ENSMUSG00000025389
KO:
mmu:17339
|
| Nucleutide sequences |
EMBL-CDS:
AAC03168.1,
AAC52416.1,
BAC35401.1,
BAC35402.1,
BAE22916.1
Ensembl_TRS:
ENSMUST00000026455
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026455
RefSeq:
NP_032626.2
|
| Others |
UniRef100:
UniRef100_P51180
UniRef90:
UniRef90_P30301
UniRef50:
UniRef50_P30301
UniGene:
Mm.31625,
Mm.396469
CCDS:
CCDS24265.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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