| Type | Description |
|---|---|
| Definition | milk fat globule-EGF factor 8 protein |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:26:00 | Knockdown of milk-fat globule EGF factor-8 suppresses glioma progression in GL261 glioma cells by repressing microglial M2 polarization. | 32324268 |
| 2020-04-04 10:44:00 | The expressions of MFG-E8 in murine and human angiosarcoma (AS) cells were significantly higher than those in melanoma cells, macrophages and endothelial cells. Depletion of MFG-E8 in murine AS cells by siRNA significantly inhibited the formation of capillary-like structures and migration. AS-derived MFG-E8 might enhance tumor growth via angiogenesis and the induction of TAMs in autocrine/paracrine manner. | 31447183 |
| 2019-12-28 11:54:00 | MFG-E8 promoted the proinflammatory phenotypic shift of aged VSMCs and arteries, rendering the vasculature prone to vascular diseases. MFG-E8 may constitute a novel therapeutic target for retarding the aging processes in such vessels. | 31470852 |
| 2019-12-14 11:43:00 | MFG-E8, as a candidate molecule to evaluate airway inflammation and remodeling, could be a potential target for the management and prevention of asthma exacerbations, suggesting that MFG-E8/integrin beta3 signaling may serve as a promising therapeutic agent for childhood asthma. | 30076648 |
| 2019-11-09 12:26:00 | Vasculopathy-induced dysfunction of pericytes and endothelial cells, the main cells secreting MFG-E8, may be associated with the decreased expression of MFG-E8 in systemic sclerosis (SSc) and that the deficient inhibitory regulation of latent TGFbeta-induced skin fibrosis by MFG-E8 may be involved in the pathogenesis of SSc and may be a therapeutic target for fibrosis in SSc patients. | 30175895 |
| Type | IDs |
|---|---|
| Synonymous | AA408458, AI325141, MFG-E8, MP47, Mfgm, P47, SED1, lactadherin |
| Gene |
UniProtKB-ID:
MFGM_MOUSE,
Q3TDU5_MOUSE
UniprotKB:
P21956,
Q3TDU5
UniParc:
UPI0000023548,
UPI0000023547,
UPI000000D080
EMBL:
AK170935,
M38337,
AK171143,
AK152088,
AK148371,
BC003904,
AK169997,
AB021130,
Y11684,
AB025280,
BC003892,
AK089211
Ensembl:
ENSMUSG00000030605
KO:
mmu:17304
|
| Nucleutide sequences |
EMBL-CDS:
BAA76386.1,
AAH03904.1,
AAH03892.1,
AAA39534.1,
BAA35180.1,
BAC40794.1,
BAE42274.1,
CAA72380.2,
BAE30938.1,
BAE28512.1,
BAE42127.1,
BAE41503.1
Ensembl_TRS:
ENSMUST00000107409,
ENSMUST00000032825
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032825,
ENSMUSP00000103032
RefSeq:
NP_001038954.1,
NP_032620.2
|
| Others |
UniRef100:
UniRef100_P21956,
UniRef100_Q3TDU5
UniRef90:
UniRef90_P21956
UniRef50:
UniRef50_P21956
UniGene:
Mm.1451
CCDS:
CCDS39989.1,
CCDS21379.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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