| Type | Description |
|---|---|
| Definition | meprin 1 beta |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:20:00 | Meprin-beta enhances ischemia reperfusion-induced kidney injury in part by modulating mediators of the signaling pathway. | 32174142 |
| 2020-04-04 12:46:00 | meprin-beta activity enhances diabetic kidney injury in part by altering the metabolite balance in kidneys, favoring high levels of uremic toxins such as indoxyl sulfate and N-methyl-pyridone-carboxamide | 31411076 |
| 2018-11-03 12:04:00 | Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition. | 28059112 |
| 2018-08-04 10:37:00 | This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease | 29166602 |
| 2018-05-26 10:58:00 | Meprin alphabeta knockout (alphabetaKO) mice and their wild-type (WT) counterparts to streptozotocin-induced type 1 diabetes. The 18-week survival rates were significantly lower for diabetic meprin alphabetaKO mice when compared to those for their wild type counterparts. | 28804725 |
| Type | IDs |
|---|---|
| Synonymous | Mep-1b |
| Gene |
UniProtKB-ID:
MEP1B_MOUSE
UniprotKB:
Q61847
UniParc:
UPI0000D626E8,
UPI000047501F
EMBL:
CH466557,
BC125627,
BC145979,
L15193
Ensembl:
ENSMUSG00000024313
KO:
mmu:17288
|
| Nucleutide sequences |
EMBL-CDS:
AAI25628.1,
AAA75234.1,
AAI45980.1,
EDK96962.1
Ensembl_TRS:
ENSMUST00000082235
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000080866
RefSeq:
NP_032612.2
|
| Others |
UniRef100:
UniRef100_Q61847
UniRef90:
UniRef90_Q61847
UniRef50:
UniRef50_Q61847
UniGene:
Mm.2682
CCDS:
CCDS37747.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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