| Type | Description |
|---|---|
| Definition | SMN (human Survival Motor Neuron gene) homolog |
| Date | Results | Publications |
|---|---|---|
| 2018-02-10 11:41:00 | Diminished SMN-1 levels caused defects in neuromuscular function, and smn-1 genetic interactions were consistent with an endocytic defect. | 27402754 |
| 2018-02-10 10:49:00 | Collectively, these results suggest decreased SMN leads to defective microRNA function via MEL-46 misregulation, followed by increased M2 muscarinic receptor expression, and neuronal dysfunction in Spinal Muscular Atrophy. | 28463115 |
| 2017-09-23 10:33:00 | Major sperm protein domain (MSPd) of VAPB homolog VPR-1 signaling is sufficient to remodel the muscle mitochondrial reticulum during adulthood. An suppressor screen identified survival of motor neuron 1 (SMN-1) as a downstream effector. | 28634272 |
| 2017-07-15 11:29:00 | We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype | 27260405 |
| 2014-01-18 10:04:00 | Data indicate that knocking down Y47D3A.22/mib-1 improves neuromuscular function in Caenorhabditis elegans deficient in SMN-1. | 23615451 |
| Type | IDs |
|---|---|
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
NP_001366985.1,
NP_001369994.1
|
| Others |
UniGene:
Cel.18372
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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