| Type | Description |
|---|---|
| Definition | mahogunin, ring finger 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:53:00 | E3 ubiquitin-protein ligase MGRN1 (MGRN1) localizes to mitochondria, and mitochondria in cells from Mgrn1 null mutant mice display fragmentation and depolarization without recruitment of the parkin E3 ubiquitin ligase. The late onset of pathology in the brains of Mgrn1 null mutant mice suggests that a further, age-dependent effect on mitochondrial homeostasis is required to trigger vacuolation. | 31089807 |
| 2019-08-10 11:02:00 | Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system. | 30230921 |
| 2018-01-30 09:50:00 | Mgrn1 can negatively regulate signaling through the Hedgehog pathway by reducing cell-surface and ciliary levels of Smoothened, an oncoprotein that transmits the Hedgehog signal across the membrane. | 29290584 |
| 2017-09-09 10:24:00 | With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. | 28475871 |
| 2016-10-22 11:17:00 | Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase inclusions likely through autophagic pathway. | 26607786 |
| Type | IDs |
|---|---|
| Synonymous | 2610042J20Rik, mKIAA0544, md, nc |
| Gene |
UniProtKB-ID:
MGRN1_MOUSE
UniprotKB:
Q9D074
UniParc:
UPI000002993D,
UPI0001DCAD21,
UPI00005ACCAC,
UPI0000DAC996,
UPI00004CB130
EMBL:
AK150176,
AK034100,
AK129161,
AK088533,
AK153407,
AK011747,
BC046830
Ensembl:
ENSMUSG00000022517
KO:
mmu:17237
|
| Nucleutide sequences |
EMBL-CDS:
BAE31967.1,
BAC97971.1,
BAE29360.1,
BAC28587.1,
BAC40408.1,
BAB27816.2,
AAH46830.1
Ensembl_TRS:
ENSMUST00000230990,
ENSMUST00000070658,
ENSMUST00000229038,
ENSMUST00000023159
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000023159,
ENSMUSP00000068314,
ENSMUSP00000155425,
ENSMUSP00000155034
RefSeq:
NP_083933.1,
NP_001365942.1,
NP_001239366.1,
NP_001365943.1,
NP_001365941.1,
NP_001343991.1,
XP_006521900.1,
NP_001343990.1,
NP_001365944.1
|
| Others |
UniRef100:
UniRef100_Q9D074
UniRef90:
UniRef90_Q9D074
UniRef50:
UniRef50_O60291-2
UniGene:
Mm.291326,
Mm.391848
CCDS:
CCDS57016.1,
CCDS49751.1,
CCDS88868.1,
CCDS88869.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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