| Type | Description |
|---|---|
| Definition | melanophilin |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 12:38:00 | propose that Rab36 stimulates RILPL2 to interact with the myosin-5a GTD; this interaction then induces exposure of the melanophilin-binding site in the GTD, enabling melanophilin to interact with the GTD and activate myosin-5a motor activity | 31175157 |
| 2018-05-19 10:52:00 | When actin and microtubules were present simultaneously, melanophilin's phosphorylation state enforced track selection of the Rab27a/melanophilin/myosin Va transport complex. | 28559319 |
| 2014-06-07 11:26:00 | The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin. | 24584932 |
| 2013-12-14 11:23:00 | Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa motors by 17-fold. | 23979131 |
| 2013-04-13 11:30:00 | Data suggest that Rab27a and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a/Mlph/MyoVa regulating cortical actin stability upstream of Rab27a/b/Munc13-4-dependent granule exocytosis. | 23281710 |
| Type | IDs |
|---|---|
| Synonymous | 2210418F23Rik, 5031433I09Rik, AW228792, D1Wsu84e, Slac-2a, l(1)-3Rk, l1Rk3, ln |
| Gene |
UniProtKB-ID:
MELPH_MOUSE,
A0A0R4J075_MOUSE
UniprotKB:
Q91V27,
A0A0R4J075
UniParc:
UPI00000E82B2,
UPI0000027F70
EMBL:
AB057759,
AC118682,
AK148274,
AF384098
Ensembl:
ENSMUSG00000026303
KO:
mmu:171531
|
| Nucleutide sequences |
EMBL-CDS:
BAE28452.1,
AAK97435.1,
BAB41087.1
Ensembl_TRS:
ENSMUST00000027528
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027528
RefSeq:
XP_006529294.1,
NP_443748.2
|
| Others |
UniRef100:
UniRef100_Q91V27,
UniRef100_A0A0R4J075
UniRef90:
UniRef90_Q91V27
UniRef50:
UniRef50_Q91V27
UniGene:
Mm.105208
CCDS:
CCDS15155.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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