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171469 Gpr37l1

171469

Gpr37l1

G protein-coupled receptor 37-like 1

protein-coding

Mus musculus

基因描述

Type Description
Definition G protein-coupled receptor 37-like 1

研究结论

Date Results Publications
2020-01-11 11:44:00 Our findings show that in the kidney, GPR37L1 participates in renal proximal tubule luminal sodium transport and regulation of blood pressure by increasing the renal expression and function of NHE3 by decreasing cAMP production. 30566002
2019-05-04 12:46:00 Gpr37l1 genetic ablation, in Ptch1(+/-) model animals, results in marked deferment of medulloblastoma occurrence and decreased incidence of aggressive tumor types. 30452905
2019-03-23 12:09:00 Despite its absence in the heart and kidney, GPR37L1 regulates baseline blood pressure in female mice and is crucial for cardiovascular compensatory responses in males. The expression of GPR37L1 in the brain, yet absence from peripheral cardiovascular tissues, suggests this orphan receptor is a hitherto unknown contributor to central cardiovascular control. 29625592
2018-07-07 11:48:00 This study demonstrated that GPR37L1 protects neurons during ischemia, presumably by modulating extracellular glutamate concentration and NMDAR activation. 28795439
2018-05-19 11:48:00 K349N substitution in Gpr37L1 did not grossly alter receptor expression, surface trafficking or constitutive signaling in transfected cells. In vivo studies revealed that a complete loss of Gpr37L1 function in mice results in increased seizure susceptibility. Mice lacking the related receptor Gpr37 also exhibited an increase in seizure susceptibility, while genetic deletion of both receptors resulted greater vulnerability 28688853

名称对应

Type IDs
Synonymous AW047233, CAG-18, D0Kist8
Gene
UniProtKB-ID: G37L1_MOUSE, A1L151_MOUSE
UniprotKB: Q99JG2, A1L151
UniParc: UPI00000228D2, UPI00001ED6DC
EMBL: AY255561, BC098482, BC127620, AJ306538, AJ306537, AB016602, BC127619
Ensembl: ENSMUSG00000026424
KO: mmu:171469
Nucleutide sequences
EMBL-CDS: BAA32062.1, CAC34842.1, AAO85073.1, CAC34843.1, AAI27621.1, AAH98482.2, AAI27620.1
Ensembl_TRS: ENSMUST00000027682
Protein sequencees
Ensembl_PRO: ENSMUSP00000027682
RefSeq: NP_602320.2
Others
UniRef100: UniRef100_Q99JG2
UniRef90: UniRef90_O60883
UniRef50: UniRef50_O60883
UniGene: Mm.272290
CCDS: CCDS48371.1

全选

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