| Type | Description |
|---|---|
| Definition | alkaline ceramidase 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-08-04 11:19:00 | Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice. | 29056331 |
| 2018-02-24 10:51:00 | In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling. | 29395079 |
| 2010-01-21 00:00:00 | novel alkaline ceramidase with a stringent substrate specificity and is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-p, as well as complex sphingolipids. | 12783875 |
| Type | IDs |
|---|---|
| Synonymous | 2310024P18Rik, AI662009, Alkcdase1, Asah3, Cer1 |
| Gene |
UniProtKB-ID:
ACER1_MOUSE
UniprotKB:
Q8R4X1
UniParc:
UPI000002870C
EMBL:
AF347023,
BC130254,
AK075884,
AK028901
Ensembl:
ENSMUSG00000045019
KO:
mmu:171168
|
| Nucleutide sequences |
EMBL-CDS:
AAL83821.1,
BAC26186.1,
AAI30255.1,
BAC36029.1
Ensembl_TRS:
ENSMUST00000056113
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000062037
RefSeq:
NP_783858.1
|
| Others |
UniRef100:
UniRef100_Q8R4X1
UniRef90:
UniRef90_Q8R4X1
UniRef50:
UniRef50_Q8TDN7
UniGene:
Mm.218784
CCDS:
CCDS28919.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29395079 |
Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation. Biochem. Biophys. Res. Commun. Patrick Münzer , Sophie Mittelstädt , Sascha Geue , Mailin-Christin Manke , Britta Walker-Allgaier , Florian Lang , Meinrad Gawaz , Oliver Borst |
2018-02-12 | - |
| 29056331 |
Stem Cell Reports Chih-Li Lin , Ruijuan Xu , Jae Kyo Yi , Fang Li , Jiang Chen , Evan C Jones , Jordan B Slutsky , Liqun Huang , Basil Rigas , Jian Cao , Xiaoming Zhong , Ashley J Snider , Lina M Obeid , Yusuf A Hannun , Cungui Mao |
2017-11-14 | - |
| 27126290 |
J. Pathol. Kifayathullah Liakath-Ali , Valerie E Vancollie , Christopher J Lelliott , Anneliese O Speak , David Lafont , Hayley J Protheroe , Camilla Ingvorsen , Antonella Galli , Angela Green , Diane Gleeson , Ed Ryder , Leanne Glover , Gema Vizcay-Barrena , Natasha A Karp , Mark J Arends , Thomas Brenn , Sarah Spiegel , David J Adams , Fiona M Watt , Louise van der Weyden |
2016-07-01 | - |
| 23096701 |
J. Invest. Dermatol. Zhixing Wang , Jay S Kirkwood , Alan W Taylor , Jan F Stevens , Mark Leid , Gitali Ganguli-Indra , Arup K Indra |
2013-03-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 21205794 |
Development Silvio Weber , Michaela T Niessen , Johannes Prox , Renate Lüllmann-Rauch , Annika Schmitz , Ralf Schwanbeck , Carl P Blobel , Ellen Jorissen , Bart de Strooper , Carien M Niessen , Paul Saftig |
2011-02-01 |
Adam10,
Adam17,
Adam8,
Alox12e,
Hes5,
Hey1,
Hey2,
Krt10,
Krt14,
Lor,
Acer1,
Mki67,
Notch1,
Furin,
Scd1
|
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 14681479 |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. Axel Visel , Christina Thaller , Gregor Eichele |
2004-01-01 |
Rnaset2a,
Mthfsl,
Tgtp2,
Gm11273,
Gm3063,
Gm9833,
Zkscan16,
Amd2,
Gm3776,
Gm3934,
Gm10681,
Gm4450,
Cyp2j11,
Camta1,
Zbtb48,
Sco2,
Pafah2,
Akna,
H6pd,
Smpdl3b,
Lao1,
Kifc1,
Gm20186,
Ugt2b38,
Slc15a4,
Psph,
Acacb,
Pds5b,
Ugt2b34,
Ube3c,
Hsd3b7,
Ano1,
Gpat4,
Lars2,
Xylb,
Slc22a13,
Rpp25,
Acad11,
Slc6a8,
Slc6a15,
Upb1,
Mgat4b,
Xpo1,
Slc35e4,
Pnpo,
Slc25a41,
Nt5m,
Rpn1,
Gck,
Synj1,
Cyp27a1,
Adcy4,
Adcy3,
Acly,
Ces1d,
Gldc,
Sbk1,
Barhl2,
E2f4,
Dgkz,
Rars,
Cnot6,
Slc16a6,
Aldh6a1,
Adi1,
Rdh14,
Iars,
Akr1c18,
Dusp22,
Gmpr2,
Thtpa,
Espl1,
Slc45a4,
Stk38,
Tecr,
Ldhal6b,
Ppcs,
Cyp4f15,
Slc39a3,
Slc39a6,
Me2,
Lars,
Cyp2c50,
Carns1,
Yars,
Psat1,
Slc25a45,
Acaca,
Atf5,
Eprs,
Nt5c3,
Dio3,
Ovol2,
Pi4kb,
Uap1,
Slc12a6,
Aldh1l1,
Haao,
Scml2
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员