| Type | Description |
|---|---|
| Definition | SH3 and multiple ankyrin repeat domains 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-08-11 11:46:00 | Loss of scaffold proteins via knockdown of Shank1 or Shank2, but not Shank3, led to a reduction of the number but not the unitary response of AMPAR-containing synapses. Only when both Shank1 and Shank2 were knocked down, were both the number and the unitary response of active synapses reduced. This reduction was accompanied by a decrease in NMDAR-mediated synaptic response. | 29250591 |
| 2018-02-17 11:57:00 | Desipramine produced a significant increase of Shank2 mRNA levels 7 d after acute stress exposure. | 27890541 |
| 2016-02-06 10:14:00 | Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls. | 25775468 |
| 2011-10-07 15:14:00 | Shank2E is concentrated in the apical domain of renal PT cells, specifically binds NaP(i)-IIa via PDZ interactions, and undergoes P(i)-induced internalization. | 15917299 |
| 2011-03-19 10:37:00 | Concerted action of ProSAP/Shank and Zn(2+) is essential for the structural integrity of the postsynaptic density and an important element in synapse formation, maturation and structural plasticity. | 21217644 |
| Type | IDs |
|---|---|
| Synonymous | CortBP1, ProSAP1, Spank-3 |
| Gene |
UniProtKB-ID:
SHAN2_RAT,
M0R5T5_RAT
UniprotKB:
Q9QX74,
M0R5T5
UniParc:
UPI000002B39F,
UPI000002B39E,
UPI00062E17F7,
UPI000013594F,
UPI000002B3A0,
UPI00001BB55F,
UPI000002B3A1,
UPI000002B39D
EMBL:
AJ249562,
AF141903,
AC125304,
AF060116,
AABR07072009,
AC131216,
AF159048,
AABR07006076,
AY298755,
AABR07072008,
AJ131899
Ensembl:
ENSRNOG00000050206
KO:
rno:171093
|
| Nucleutide sequences |
EMBL-CDS:
AAD42977.1,
CAB56522.1,
CAB44313.1,
AAC62226.1,
AAF02497.1,
CAB44314.1,
AAP85236.1,
CAB44312.1
Ensembl_TRS:
ENSRNOT00000071741,
ENSRNOT00000075078,
ENSRNOT00000092516,
ENSRNOT00000092386,
ENSRNOT00000092357,
ENSRNOT00000071484
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000065891,
ENSRNOP00000075919,
ENSRNOP00000075839,
ENSRNOP00000075800,
ENSRNOP00000067841,
ENSRNOP00000064763
RefSeq:
XP_017444214.1,
XP_017444213.1,
NP_001004133.1,
XP_017444212.1,
XP_017444204.1,
XP_017444205.1,
NP_958738.1,
XP_017444215.1,
XP_017444211.1,
XP_017444207.1,
XP_017444216.1,
XP_017444210.1,
NP_597685.1,
NP_597684.1,
XP_017444208.1,
XP_017444206.1,
XP_008758290.1,
XP_017444209.1
|
| Others |
UniRef100:
UniRef100_M0R5T5,
UniRef100_Q9QX74
UniRef90:
UniRef90_Q9QX74,
UniRef90_Q9QX74-7
UniRef50:
UniRef50_Q9QX74,
UniRef50_Q9QX74-7
UniGene:
Rn.14545
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Ensembl: {{protein.proteinEnsembl}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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