Cyb5r4 - cytochrome b5 reductase 4-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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171015 Cyb5r4

基因描述

Type	Description
Definition	cytochrome b5 reductase 4

研究结论

Date	Results	Publications
2010-01-21 00:00:00	G179 was required for both effective NADH/NADPH selectivity & to maintain the correct orientation & position of the conserved cysteine in the proline-rich "CGpppM" motif that is critical for optimum NADH binding & efficient hydride transfer in cb5r.	16216070

名称对应

Type	IDs
Synonymous	Ncb5or, b5&b5R, b5+b5R, cb5/cb5R
Gene	UniProtKB-ID: NB5R4_RAT, A0A0G2JSK2_RAT UniprotKB: Q68EJ0, A0A0G2JSK2 UniParc: UPI000150AF0A, UPI000154EAFA, UPI000150AF0B EMBL: AABR07073433, BC080240, CH473954, AF307840, AC117045, AY321371, AY321370 Ensembl: ENSRNOG00000010024 KO: rno:171015
Nucleutide sequences	EMBL-CDS: AAQ83903.1, AAG45053.1, AAH80240.1, AAQ83902.1, EDL77606.1 Gene_ORFName: rCG_25399 Ensembl_TRS: ENSRNOT00000013908
Protein sequencees	Ensembl_PRO: ENSRNOP00000013909 RefSeq: XP_006243534.1, NP_596918.3, XP_017450917.1
Others	UniRef100: UniRef100_Q68EJ0, UniRef100_A0A0G2JSK2 UniRef90: UniRef90_Q3TDX8 UniRef50: UniRef50_Q3TDX8 UniGene: Rn.3334

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
17343567	The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response. Biochem. J. Kevin Larade , Zhi-gang Jiang , Andre Dejam , Hao Zhu , H Franklin Bunn	2007-06-15	Cyb5r4
16216070	Mutagenesis of Glycine 179 modulates both catalytic efficiency and reduced pyridine nucleotide specificity in cytochrome b5 reductase. Biochemistry Glenn W Roma , Louis J Crowley , C Ainsley Davis , Michael J Barber	2005-10-18	Cyb5r4
15504981	Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus. Diabetes Gitte Andersen , Lise Wegner , Christian Schack Rose , Jianxin Xie , Hao Zhu , Kevin Larade , Anders Johansen , Jakob Ek , Jeannet Lauenborg , Thomas Drivsholm , Knut Borch-Johnsen , Peter Damm , Torben Hansen , H Franklin Bunn , Oluf Pedersen	2004-11-01	-
15247412	Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc. Natl. Acad. Sci. U.S.A. Jianxin Xie , Hao Zhu , Kevin Larade , Annie Ladoux , Ayden Seguritan , Michelle Chu , Susumu Ito , Roderick T Bronson , Edward H Leiter , Chen-Yu Zhang , Evan D Rosen , H Franklin Bunn	2004-07-20	Cyb5r4, Cyb5r4
15131110	NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J Biol Chem Hao Zhu , Kevin Larade , Timothy A Jackson , Jianxin Xie , Annie Ladoux , Helmut Acker , Utta Berchner-Pfannschmidt , Joachim Fandrey , Andrew R Cross , Gudrun S Lukat-Rodgers , Kenton R Rodgers , H Franklin Bunn	2004-07-16	-
14962668	Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase. Genomics Benjamin J Curry , Shaun D Roman , Ceanne A Wallace , Rebecca Scott , Elana Miriami , R John Aitken	2004-03-01	Cyb5r4, Cyb5r4
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-
11913972	Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands. Arch. Biochem. Biophys. C Ainsley Davis , Ish K Dhawan , Michael K Johnson , Michael J Barber	2002-04-01	Cyb5r4, Cyb5r4, Cyb5r3, Cyb5a
10611283	Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc. Natl. Acad. Sci. U.S.A. H Zhu , H Qiu , H W Yoon , S Huang , H F Bunn	1999-12-21	-

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