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170848 Kcnq2

170848

Kcnq2

potassium voltage-gated channel subfamily Q member 2

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition potassium voltage-gated channel subfamily Q member 2

研究结论

Date Results Publications
2019-04-06 11:03:00 the M channel is not expressed in rat adrenal medulla cells and this absence of expression may be ascribed to the suppression by glucocorticoid activity. 29488002
2019-03-09 11:50:00 Our results suggest that KCNQ2 channels are involved in regulating orofacial cold sensitivity 29133175
2018-10-27 10:03:00 RNA interference-mediated silencing of KCNQ2 is a suitable approach to create an ex vivo model for testing the specificity of novel Kv7.2/Kv7.3 agonists. 29212407
2018-06-02 10:26:00 These results reveal for the first time that a mutation-induced decrease in current sensitivity to PIP2 is the primary molecular defect responsible for Kv7.2-EE in individuals carrying the R325G variant, further expanding the range of pathogenetic mechanisms exploitable for personalized treatment of Kv7.2-related epilepsies. 27905566
2017-09-09 11:07:00 KCNQ2 and KCNQ3 play an important role in neuronal differentiation of PC12 cells as measured by neurite growth. Depression of these KCNQs can promote neuronal differentiation, which is related to membrane depolarization and subsequent activation of Ca2+ influx through T type Ca2+ channels. 27450567

名称对应

Type IDs
Gene
UniProtKB-ID: KCNQ2_RAT
UniprotKB: O88943
UniParc: UPI000002A684, UPI000002A67E, UPI000002A683, UPI000002A67D, UPI00001279EE, UPI000002A682, UPI000002A680, UPI000002A67F, UPI000002A681
EMBL: AF087453
KO: rno:170848
Nucleutide sequences
EMBL-CDS: AAC36722.1
Protein sequencees
RefSeq: XP_017446936.1, XP_006235789.1, XP_017446934.1, XP_006235791.1, XP_017446935.1, XP_006235783.1, XP_017446932.1, XP_008760684.1, XP_017446930.1, NP_579856.2, XP_017446931.1, XP_006235787.1, XP_017446933.1
Others
UniRef100: UniRef100_O88943
UniRef90: UniRef90_O43526
UniRef50: UniRef50_O43526
UniGene: Rn.33317

全选

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