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17060 Blnk

17060

Blnk

B cell linker

protein-coding

Mus musculus

基因描述

Type Description
Definition B cell linker

研究结论

Date Results Publications
2017-09-16 12:07:00 The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway. 26522721
2016-08-06 10:46:00 Authors demonstrate leukemogenicity of PAX5-PML by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5-PML in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5-PML. 26703467
2013-08-03 10:29:00 B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. 23534976
2012-12-08 10:02:00 Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B in the B cell lineage. 22956576
2012-09-22 11:21:00 a novel negative feedback regulation of BCR signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK 22334673

名称对应

Type IDs
Synonymous BASH, Bca, Ly-57, Ly57, Lyw-57, SLP-65
Gene
UniProtKB-ID: BLNK_MOUSE
UniprotKB: Q9QUN3
UniParc: UPI00000298FF
EMBL: AJ298054, BC059785, AB015290, AF068182, Y17159
Ensembl: ENSMUSG00000061132
KO: mmu:17060
Nucleutide sequences
EMBL-CDS: CAA76666.1, CAC18565.1, BAA34944.1, AAC40206.1, AAH59785.1
Ensembl_TRS: ENSMUST00000054769
Protein sequencees
Ensembl_PRO: ENSMUSP00000057844
RefSeq: NP_001351983.1, NP_032554.2
Others
UniRef100: UniRef100_Q9QUN3
UniRef90: UniRef90_Q9QUN3
UniRef50: UniRef50_Q8WV28-3
UniGene: Mm.9749
CCDS: CCDS37983.1

全选

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研究热度

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