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170484 Nphs2

170484

Nphs2

nephrosis 2, podocin

protein-coding

Mus musculus

基因描述

Type Description
Definition nephrosis 2, podocin

研究结论

Date Results Publications
2021-03-13 13:18:00 Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury. 32907879
2017-11-11 13:45:00 While R140Q podocin mRNA expression was elevated, protein abundance was reduced by more than 50% within one week following induction 29049388
2017-01-28 11:20:00 Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from cultured podocytes and native glomeruli. Ubiquitylomic analysis of mouse glomeruli revealed that podocin is ubiquitylated at two lysine residues. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. 26792178
2014-06-21 12:36:00 ATP evokes activation of TRPC6 channels in podocytes through P2Y receptors, podocin, and generation of reactive oxygen species. 24553432
2014-06-07 10:05:00 the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity. 24596097

名称对应

Type IDs
Synonymous PDCN, SRN1
Gene
UniProtKB-ID: PODO_MOUSE, C0LL94_MOUSE
UniprotKB: Q91X05, C0LL94
UniParc: UPI0000022956
EMBL: FJ715770, AJ302048, AK052746, BC067401, AY050309
Ensembl: ENSMUSG00000026602
KO: mmu:170484
Nucleutide sequences
EMBL-CDS: CAC44636.1, BAC35128.1, AAL06146.1, AAH67401.1, ACN67095.1
Ensembl_TRS: ENSMUST00000027896
Protein sequencees
Ensembl_PRO: ENSMUSP00000027896
RefSeq: XP_011237067.1, XP_006496747.1, NP_569723.1, XP_006496746.1
Others
UniRef100: UniRef100_Q91X05
UniRef90: UniRef90_Q91X05
UniRef50: UniRef50_Q9NP85
UniGene: Mm.289099
CCDS: CCDS15391.1

全选

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