| Type | Description |
|---|---|
| Definition | lanosterol synthase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:02:00 | Study identified two patients with novel biallelic LSS mutations who exhibited congenital hypotrichosis and midline anomalies but did not have cataracts. Epidermis-specific Lss knockout mice showed neonatal lethality due to dehydration, indicating that LSS could be involved in skin barrier integrity. Knockout of Lss in the epidermis caused hypotrichosis in adult mice. Lens-specific Lss knockout mice had cataracts. | 32101538 |
| 2016-03-26 11:31:00 | liver-specific ablation of squalene synthase inhibits hepatic cholesterol biosynthesis and induces hypolipidemia without increasing significant mortality. | 25755092 |
| 2010-01-21 00:00:00 | Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. | 19119143 |
| Type | IDs |
|---|---|
| Synonymous | 2810025N20Rik, D10Ertd116e, Osc |
| Gene |
UniProtKB-ID:
LSS_MOUSE
UniprotKB:
Q8BLN5
UniParc:
UPI00000287E6
EMBL:
AK044016,
AK078023,
BC029082
Ensembl:
ENSMUSG00000033105
KO:
mmu:16987
|
| Nucleutide sequences |
EMBL-CDS:
AAH29082.1,
BAC37102.1,
BAC31739.1
Ensembl_TRS:
ENSMUST00000048678
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046856
RefSeq:
XP_030100782.1,
NP_666118.1,
XP_036011544.1,
XP_036011545.1,
XP_006513347.1
|
| Others |
UniRef100:
UniRef100_Q8BLN5
UniRef90:
UniRef90_P48450
UniRef50:
UniRef50_P48450
UniGene:
Mm.55075
CCDS:
CCDS23948.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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