| Type | Description |
|---|---|
| Definition | SH2B adaptor protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 10:58:00 | The requirement of PI3K-Akt activation for the cardioprotective effect of Lnk was confirmed. | 31301301 |
| 2020-01-11 10:39:00 | Study identified a role for LNK (SH2B3) in the pathology of aortic dissection in experimental animals and humans and described a new model that can be used to inform both inherited and acquired forms of this disease. | 30333305 |
| 2019-11-30 10:39:00 | Lnk regulates adipose inflammation and glucose tolerance through group 1 innate lymphoid cells. | 30110639 |
| 2019-06-08 12:02:00 | Study found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by and suppresses interferon induced cell cycle arrest and cell apoptosis. | 31110180 |
| 2019-01-19 10:50:00 | Data indicate that linker of T-cell receptor pathways protein(Lnk) deficiency restores phenotypic hematopoietic stem cells (HSCs) in Fanconi anemia, complementation group D2 protein knockout (Fancd2-/-) mice. | 30254368 |
| Type | IDs |
|---|---|
| Synonymous | AI429800, Lnk |
| Gene |
UniProtKB-ID:
SH2B3_MOUSE,
D3Z3Y5_MOUSE
UniprotKB:
O09039,
D3Z3Y5
UniParc:
UPI0000F4EE8C,
UPI0000024DD0
EMBL:
U89993,
BC006759,
AC113302,
U89992
Ensembl:
ENSMUSG00000042594
KO:
mmu:16923
|
| Nucleutide sequences |
EMBL-CDS:
AAB58580.2,
AAB58581.1,
AAH06759.1
Ensembl_TRS:
ENSMUST00000040308,
ENSMUST00000086310,
ENSMUST00000122426,
ENSMUST00000118580
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000083490,
ENSMUSP00000041611,
ENSMUSP00000113926,
ENSMUSP00000113808
RefSeq:
XP_036020726.1,
NP_032533.1,
XP_006530234.1,
NP_001293056.1,
NP_001293055.1,
NP_001293057.1,
XP_006530236.1,
XP_006530235.1,
XP_006530233.1
|
| Others |
UniRef100:
UniRef100_D3Z3Y5,
UniRef100_O09039
UniRef90:
UniRef90_O09039
UniRef50:
UniRef50_Q9UQQ2
UniGene:
Mm.65493
CCDS:
CCDS19641.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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