| Type | Description |
|---|---|
| Definition | LIM homeobox transcription factor 1 beta |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 10:31:00 | The authors report that LIM homeodomain factor 1b (Lmx1b)-deficient serotonin (5-HT) neurons fail to generate axonal projections to the forebrain and spinal cord. Stage-specific targeting demonstrates that Lmx1b is required at successive stages to control 5-HT axon primary outgrowth, selective routing, and terminal arborization. | 31355748 |
| 2019-10-05 10:31:00 | identified a novel NPS-causing LMX1B mutation and expanded the spectrum of mutations in the LMX1B gene. The c.712_714delTTC mutation may affect the quaternary structure of LMX1B, which is essential for the specification of dorsal limb fate at both zeugopodal and autopodal levels, leading to typical NPS | 31053111 |
| 2018-12-29 11:01:00 | Authors conclude that Lmx1b plays a key role as an anti-osteogenic factor in patterning the head mesenchyme into areas with different osteogenic competence. In turn, this patterning event is crucial to generating the proper organization of the bones and soft tissue joints of the calvaria. | 29852132 |
| 2018-02-10 10:29:00 | Data show that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons. | 27407143 |
| 2018-02-10 10:03:00 | Lmx1b is required for the topographical organization of dopaminergic innervation in the striatum.Lmx1b regulates Plxnc1 expression. | 29038581 |
| Type | IDs |
|---|---|
| Synonymous | Icst, LMX1.1, LMX1.2 |
| Gene |
UniProtKB-ID:
LMX1B_MOUSE,
A0A6I8MWW7_MOUSE,
A0A0R4J0I7_MOUSE
UniprotKB:
O88609,
A0A6I8MWW7,
A0A0R4J0I7
UniParc:
UPI0001CE94CF,
UPI000002AD5B,
UPI0000F4D3E0
EMBL:
BC125469,
AL929212,
AF078166,
CH466542,
BC119169
Ensembl:
ENSMUSG00000038765
KO:
mmu:16917
|
| Nucleutide sequences |
EMBL-CDS:
CAM26554.1,
AAC27793.1,
EDL08602.1,
AAI19170.1,
AAI25470.1
Ensembl_TRS:
ENSMUST00000239476,
ENSMUST00000041730
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000159290,
ENSMUSP00000043616
RefSeq:
NP_034855.3,
XP_006497809.1
|
| Others |
UniRef100:
UniRef100_A0A0R4J0I7,
UniRef100_O88609
UniRef90:
UniRef90_O88609,
UniRef90_O60663
UniRef50:
UniRef50_O60663
UniGene:
Mm.39825
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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