| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:33:00 | Macrophage pyroptosis is mediated by immunoproteasome subunit beta5i (LMP7) in abdominal aortic aneurysm. | 33019975 |
| 2020-12-26 13:14:00 | Ablation of Immunoproteasome beta5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice. | 31636038 |
| 2020-07-11 11:03:00 | This study provides new evidence of the critical role of beta5i in deoxycorticosterone-acetate-salt-induced cardiac remodeling. | 31629736 |
| 2020-05-09 12:12:00 | Knockout of beta5i(PSMB8) in cardiomyocytes and mice markedly attenuated the hypertrophic response, and this effect was aggravated by beta5i overexpression in cardiomyocytes. beta5i interacted with and promoted ATG5 degradation thereby leading to inhibition of autophagy and cardiac hypertrophy. | 31086810 |
| 2019-10-26 10:37:00 | results provide, to our knowledge, novel evidence that ablation or pharmacological inhibition of LMP7 attenuates Ang II-induced abdominal aortic aneurysm (AAA) formation, and LMP7 might be a novel therapeutic target for treating AAA in humans | 30642978 |
| Type | IDs |
|---|---|
| Synonymous | Lmp-7, Lmp7 |
| Gene |
UniProtKB-ID:
PSB8_MOUSE
UniprotKB:
P28063
UniParc:
UPI0000000111
EMBL:
X64449,
AK150674,
AK159971,
U22032,
BC051450,
U22033,
AK146182,
AF027865,
L11145,
BC013785,
AK031801,
U22031,
AK050627,
U22034,
Z21847,
U22035
Ensembl:
ENSMUSG00000024338
KO:
mmu:16913
|
| Nucleutide sequences |
EMBL-CDS:
AAH51450.1,
AAA75036.1,
AAA75034.1,
BAE20682.1,
BAE35524.1,
BAC27555.1,
AAB81532.1,
AAB46392.1,
CAB60065.1,
CAA45780.1,
AAA75033.1,
AAA75035.1,
CAA45779.1,
AAH13785.1,
BAE26960.1,
AAA75037.1,
BAE29756.1
Ensembl_TRS:
ENSMUST00000025196
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025196
RefSeq:
NP_034854.2
|
| Others |
UniRef100:
UniRef100_P28063
UniRef90:
UniRef90_P28063
UniRef50:
UniRef50_P28063
UniGene:
Mm.180191,
Mm.484878
CCDS:
CCDS50073.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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