| Type | Description |
|---|---|
| Definition | LIM domain only 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-02 10:28:00 | NHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML, associated with a loss of multipotent progenitors in the bone marrow. Thus multiple T cell oncogenes induce thymocyte self-renewal via Lmo2/Lyl1. | 30700838 |
| 2019-03-30 10:55:00 | Transient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression, and histologically, transcriptionally, and genetically similar to human LMO2-driven T-ALL. | 29880602 |
| 2018-08-11 11:26:00 | Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors. | 29778661 |
| 2017-10-21 12:34:00 | Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program. | 28973433 |
| 2017-08-12 12:32:00 | DNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling. | 27118408 |
| Type | IDs |
|---|---|
| Synonymous | Rbtn-2, Rbtn2, Rhom-2, Ttg2 |
| Gene |
UniProtKB-ID:
RBTN2_MOUSE,
Q544Z2_MOUSE,
A2BHP5_MOUSE,
A2BHP3_MOUSE
UniprotKB:
P25801,
Q544Z2,
A2BHP5,
A2BHP3
UniParc:
UPI0000D77898,
UPI0000003F0B,
UPI0000D77899
EMBL:
BX640578,
M64360,
AK013416,
BC057880
Ensembl:
ENSMUSG00000032698
KO:
mmu:16909
|
| Nucleutide sequences |
EMBL-CDS:
AAH57880.1,
AAA40054.1,
BAB28844.1
Ensembl_TRS:
ENSMUST00000170926,
ENSMUST00000123437,
ENSMUST00000111143,
ENSMUST00000111140
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000117703,
ENSMUSP00000128317,
ENSMUSP00000106773,
ENSMUSP00000106770
RefSeq:
NP_001135808.1,
NP_001135807.1,
XP_006498883.1,
NP_032531.2,
NP_001135809.1
|
| Others |
UniRef100:
UniRef100_P25801,
UniRef100_A2BHP5
UniRef90:
UniRef90_P25801
UniRef50:
UniRef50_P25801
UniGene:
Mm.29266
CCDS:
CCDS50652.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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