| Type | Description |
|---|---|
| Definition | lysosomal acid lipase A |
| Date | Results | Publications |
|---|---|---|
| 2019-10-26 10:28:00 | Data provide evidence that hepatocyte-specific LAL deficiency is sufficient to alter whole-body lipid and energy homeostasis in mice. Hepatic LAL plays a pivotal role by preventing liver damage and maintaining lipid and energy homeostasis, especially during high lipid availability. | 30639734 |
| 2019-07-13 12:28:00 | Lysosomal acid lipase has a critical role in promoting both macrophage and whole-body reverse cholesterol transport. | 29599133 |
| 2018-06-02 10:48:00 | LAL is critical for shuttling fatty acids derived from circulating lipoproteins to brown adipose tissue during cold exposure. | 29374543 |
| 2018-05-19 10:38:00 | Data show that lysosomal acid lipase (LAL)-deficient (-/-) macrophages accumulate neutral lipids, mainly cholesteryl esters, within lysosomes. | 28402950 |
| 2018-01-27 10:07:00 | Low LAL expression is associated with tumor growth and metastasis. | 28924047 |
| Type | IDs |
|---|---|
| Synonymous | AA960673, Lal, Lip-1, Lip1 |
| Gene |
UniProtKB-ID:
LICH_MOUSE,
Q3TEL5_MOUSE
UniprotKB:
Q9Z0M5,
Q3TEL5
UniParc:
UPI0000022434,
UPI00005B259B
EMBL:
AK149791,
AK164007,
Z31689,
CH466534,
AK088659,
AK169567
Ensembl:
ENSMUSG00000024781
KO:
mmu:16889
|
| Nucleutide sequences |
EMBL-CDS:
EDL41750.1,
BAE29088.1,
BAC40484.1,
CAA83494.1,
BAE37585.1,
BAE41233.1
Ensembl_TRS:
ENSMUST00000178114,
ENSMUST00000049572
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000053270,
ENSMUSP00000136967
RefSeq:
NP_067435.3,
NP_001104570.1
|
| Others |
UniRef100:
UniRef100_Q3TEL5,
UniRef100_Q9Z0M5
UniRef90:
UniRef90_Q9Z0M5
UniRef50:
UniRef50_Q9Z0M5
UniGene:
Mm.157545
CCDS:
CCDS29760.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员