| Type | Description |
|---|---|
| Definition | LIM homeobox protein 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 11:10:00 | We demonstrate that mutation of a solvent exposed side chain in the spacer region of an LHX4-ISL2 complex has no significant effect on the structure of the complex, but decreases binding affinity, apparently by increasing flexibility of the linker. | 30788856 |
| 2019-12-14 10:45:00 | The LHX4 gene is highly enriched in developing cone photoreceptors as are several new genes identified through transcriptional profiling, some of which are expressed in subclusters of cones. | 31260032 |
| 2017-10-14 13:03:00 | conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium. | 28807898 |
| 2016-01-02 11:09:00 | We discovered that expression of Cdkn1a is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 mutants. Lhx4 mutants exhibit reduced cyclin D1 expression and have auxiliary pouch-like structures. | 25668206 |
| 2012-03-31 10:05:00 | X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding. | 22025611 |
| Type | IDs |
|---|---|
| Synonymous | A330062J17Rik, Gsh-4, Gsh4 |
| Gene |
UniProtKB-ID:
LHX4_MOUSE
UniprotKB:
P53776
UniParc:
UPI0000564702
EMBL:
BC049834,
AF135415,
S71659,
U89343
Ensembl:
ENSMUSG00000026468
KO:
mmu:16872
|
| Nucleutide sequences |
EMBL-CDS:
AAC53336.1,
AAD30125.1,
AAH49834.1,
AAB31260.1
Ensembl_TRS:
ENSMUST00000027740
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027740
RefSeq:
XP_006529232.1,
NP_034842.2
|
| Others |
UniRef100:
UniRef100_P53776
UniRef90:
UniRef90_P53776
UniRef50:
UniRef50_Q969G2
UniGene:
Mm.103624,
Mm.351266
CCDS:
CCDS48399.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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