| Type | Description |
|---|---|
| Definition | lectin, galactose binding, soluble 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:10:00 | Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. | 33398185 |
| 2021-02-06 13:51:00 | Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation. | 33147994 |
| 2020-07-11 12:33:00 | Loss of Lgals1 is associated with a spontaneous inflammatory disorder that recapitulated human Sjogren's syndrome via the coordinated amplification of both innate and adaptive immune pathways. | 32161138 |
| 2020-05-30 11:00:00 | Loss of Gal1 increased liver injury, inflammation, fibrosis, and ductular reaction in Gal1-KO/Mdr2-KO dKO mice of both the C57bl/6 and the FVB/N strains starting from an early age. Gal1-mediated protection from hepatitis, liver fibrosis, and HCC initiation dominates over its known procarcinogenic activities at later stages of HCC development. | 30897344 |
| 2019-10-26 12:43:00 | Study in a murine model of prostate cancer demonstrates that endogenous Gal-1 in lymphocytes modulates their proliferative rate and cytotoxic function in conditions of high extracellular Gal-1 concentration, mainly derived from tumor cells. In such conditions, the absence of Gal-1 in T lymphocytes potentiates anti-tumor immune responses, so GAL-1 acts as a negative regulator of anti-tumor immunity. | 30319642 |
| Type | IDs |
|---|---|
| Synonymous | AA410090, Gal-1, Galbp, L-14.5, L14, Lect14, galectin-1 |
| Gene |
UniProtKB-ID:
LEG1_MOUSE
UniprotKB:
P16045
UniParc:
UPI000002D6DF
EMBL:
X51903,
X53067,
X15986,
X66532,
X51578,
M33214,
X51579,
BC099479,
M57470,
X51577,
M14087,
AK004298,
BC002063
Ensembl:
ENSMUSG00000068220
KO:
mmu:16852
|
| Nucleutide sequences |
EMBL-CDS:
AAH99479.1,
CAA47143.1,
CAA36183.1,
CAA35930.1,
AAA36172.1,
AAH02063.1,
AAA37667.1,
AAA37313.1,
CAA37242.1,
CAA34117.1
Ensembl_TRS:
ENSMUST00000089377
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000086795
RefSeq:
NP_032521.1
|
| Others |
UniRef100:
UniRef100_P16045
UniRef90:
UniRef90_P16045
UniRef50:
UniRef50_P16045
UniGene:
Mm.43831
CCDS:
CCDS27628.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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