| Type | Description |
|---|---|
| Definition | lymphocyte cytosolic protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:04:00 | Targeting adaptor protein SLP76 of as a therapeutic approach for lethal sepsis. | 33436632 |
| 2017-08-19 12:55:00 | Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT and ERK1/2, was increased | 28107427 |
| 2017-07-01 11:33:00 | slp-76 contributes to the regulation of the tissue distribution, PLZF, and cytokine expression of iNKT cells via ADAP-dependent and -independent mechanisms. | 27349342 |
| 2017-04-29 12:05:00 | findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells. | 28188290 |
| 2015-11-28 11:30:00 | immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells | 26321253 |
| Type | IDs |
|---|---|
| Synonymous | AI323664, BB161688, SLP-76, SLP76, m1Khoe, twm |
| Gene |
UniProtKB-ID:
LCP2_MOUSE
UniprotKB:
Q60787
UniParc:
UPI00000E8866
EMBL:
AK170491,
BC006948,
CH466604,
AK036727,
U20159
Ensembl:
ENSMUSG00000002699
KO:
mmu:16822
|
| Nucleutide sequences |
EMBL-CDS:
EDL23730.1,
AAH06948.1,
BAC29553.1,
BAE41833.1,
AAC52189.1
Ensembl_TRS:
ENSMUST00000052413
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000056621
RefSeq:
NP_034826.2
|
| Others |
UniRef100:
UniRef100_Q60787
UniRef90:
UniRef90_Q60787
UniRef50:
UniRef50_Q13094
UniGene:
Mm.265350
CCDS:
CCDS48768.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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