| Type | Description |
|---|---|
| Definition | rho/rac guanine nucleotide exchange factor (GEF) 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:14:00 | GEF-H1 Is Required for Colchicine Inhibition of Neutrophil Rolling and Recruitment in Mouse Models of Gout. | 33199537 |
| 2020-06-27 10:46:00 | Claudin-2 silencing activates RHOA through the exchange factor GEF-H1. | 31481470 |
| 2020-05-16 12:22:00 | Here we show that microtubule stabilization, triggered by engagement of the B cell receptor, acts as a cue to release centrosome-associated Exo70, which is redistributed to the immune synapse. This process is coupled to the recruitment and activation of GEF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of lysosomes at the immune synapse. | 31197029 |
| 2019-05-18 12:22:00 | GEF-H1 does not contribute significantly to the innate immune sensing of murine norovirus, although its function may be modulated via interaction with the viral NS3 protein. | 30634661 |
| 2019-04-20 10:49:00 | The GEF-H1-IKKepsilon-IRF5 signaling axis functions independent of NOD-like receptors and is critically required for the recognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes. | 30902986 |
| Type | IDs |
|---|---|
| Synonymous | AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651 |
| Gene |
UniProtKB-ID:
ARHG2_MOUSE,
H3BJ40_MOUSE,
H3BJ45_MOUSE
UniprotKB:
Q60875,
H3BJ40,
H3BJ45
UniParc:
UPI0000EF8856,
UPI00001F03B2,
UPI0001E92A42,
UPI0000161D93,
UPI0000565AF2,
UPI0001E92A43,
UPI000154A382
EMBL:
BC006589,
AB093254,
U28495,
AF177032,
AC145168,
X95761,
AK171223,
AK167628
Ensembl:
ENSMUSG00000028059
KO:
mmu:16800
|
| Nucleutide sequences |
EMBL-CDS:
BAC41438.1,
BAE42325.1,
CAA65067.1,
AAH06589.1,
AAG09271.1,
BAE39679.1,
AAC52234.1
Ensembl_TRS:
ENSMUST00000170653,
ENSMUST00000175911,
ENSMUST00000029694,
ENSMUST00000107510,
ENSMUST00000175779,
ENSMUST00000176500,
ENSMUST00000177498
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000127843,
ENSMUSP00000135428,
ENSMUSP00000029694,
ENSMUSP00000103134,
ENSMUSP00000135177,
ENSMUSP00000134834,
ENSMUSP00000134840
RefSeq:
XP_030108298.1,
XP_006501122.1,
NP_001185841.1,
XP_006501121.1,
XP_036018800.1,
NP_032513.3,
XP_006501129.1,
NP_001185842.1,
NP_001364055.1,
XP_036018802.1,
XP_006501130.1,
XP_030108299.1,
XP_011238329.1,
XP_006501128.1,
NP_001185840.1,
XP_036018801.1,
XP_006501123.1
|
| Others |
UniRef100:
UniRef100_Q60875,
UniRef100_H3BJ40,
UniRef100_H3BJ45
UniRef90:
UniRef90_Q60875
UniRef50:
UniRef50_Q92974
UniGene:
Mm.239329,
Mm.482396
CCDS:
CCDS57221.1,
CCDS57222.1,
CCDS17481.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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