| Type | Description |
|---|---|
| Definition | laminin, alpha 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:24:00 | Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte | 31882770 |
| 2020-06-20 12:27:00 | In diverse models, laminins alpha-4 (LAMA4) and alpha-5 (LAMA5) were differentially regulated. Immunity was associated with decreased LAMA4:LAMA5 ratio, while tolerance was associated with an increased ratio. LAMA4inhibited CD4+ T-cell proliferation and Th1, Th2, and Th17 polarization but favored Treg induction. LAMA4 and LAMA5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively. | 31343575 |
| 2018-02-24 10:17:00 | Data (including data from studies in knockout mice) suggest that Lama4 is involved in regulation of energy metabolism, regulation of adiposity, and development of beige adipose tissue; here, Lama4 knockout mice exhibit significantly improved insulin sensitivity compared with wild-type mice, suggesting improved metabolic function. | 28973559 |
| 2017-11-18 13:14:00 | Results showed maintained perturbed transmission properties at lama4(-/-) NMJs from adult (3 months) through to aged (18-22 months). Hind-limb grip force demonstrated similar trends as transmission properties, with maintained weaker grip force across age groups in lama4(-/-). Interestingly, both transmission properties and hind-limb grip force in aged wild-types resembled those observed in adult lama4(-/-). | 28301326 |
| 2017-09-09 11:49:00 | Lama4-/- NMJs demonstrated a decrease in miniature end-plate potential (EPP) frequency and increased amplitude of miniature EPPs and evoked EPPs. | 27998908 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
LAMA4_MOUSE
UniprotKB:
P97927
UniParc:
UPI00000297E8
EMBL:
U88352,
U59865,
Y09827,
U69176,
U58950,
BC115942
Ensembl:
ENSMUSG00000019846
KO:
mmu:16775
|
| Nucleutide sequences |
EMBL-CDS:
AAI15943.1,
CAA70970.1,
AAB41840.1,
AAC24725.1,
AAC53178.1,
AAC52982.1
Ensembl_TRS:
ENSMUST00000019992
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019992
RefSeq:
NP_034811.2
|
| Others |
UniRef100:
UniRef100_P97927
UniRef90:
UniRef90_P97927
UniRef50:
UniRef50_Q16363
UniGene:
Mm.258065
CCDS:
CCDS35882.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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