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16596 Klf1

16596

Klf1

Kruppel-like factor 1 (erythroid)

protein-coding

Mus musculus

基因描述

Type Description
Definition Kruppel-like factor 1 (erythroid)

研究结论

Date Results Publications
2019-11-30 12:16:00 Study shows that embryos from KLF1 Nan variant have defects in erythroid maturation. 30921348
2019-11-02 10:25:00 Mutant Nan-KLF1 leads to extensive and progressive transcriptome corruption in adult spleen erythroid precursors such that stress erythropoiesis is severely compromised. 30143664
2019-09-14 12:37:00 Insight into the mechanism of Congenital Dyserythropoietic Anemia Type IV which is caused by a point mutation in the DNA-binding domain of KLF1. This mutation alters the DNA binding specificity of KLF1 and this leads to aberrant binding in vivo at a few thousand sites scattered across the genome. 31126231
2019-08-24 11:05:00 data indicate that the cytotoxic effect of IFN-beta activation in CMEI contribute to the impairment of definitive erythropoiesis associated with Klf1 deprivation 29230002
2019-01-12 10:08:00 Results provide new evidence to support a role for KLF1 in the erythroid/megakaryocyte switch, as well as indicating that transcription factor competition is an important regulation mechanism in eukaryotes in vivo. 28600522

名称对应

Type IDs
Synonymous Eklf, Nan
Gene
UniProtKB-ID: E9QNP6_MOUSE, A0A6I8MWY6_MOUSE
UniprotKB: E9QNP6, A0A6I8MWY6
UniParc: UPI000002166F, UPI0000357F02
EMBL: AC161765
Ensembl: ENSMUSG00000054191
KO: mmu:16596
Nucleutide sequences
Ensembl_TRS: ENSMUST00000067060, ENSMUST00000239392
Protein sequencees
Ensembl_PRO: ENSMUSP00000064366, ENSMUSP00000159324
RefSeq: NP_034765.3
Others
UniRef100: UniRef100_A0A6I8MWY6
UniRef90: UniRef90_P46099
UniRef50: UniRef50_Q13351
UniGene: Mm.4847

全选

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研究热度

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