| Type | Description |
|---|---|
| Definition | potassium channel, subfamily K, member 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:50:00 | TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function. The effects of TASK-1 loss of function were associated with enhanced AKT phosphorylation and expression of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) transcription factor. | 31977249 |
| 2020-01-04 10:10:00 | Study reports that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 delays neuron loss and prolongs lifespan in this model. | 31439839 |
| 2019-11-23 10:17:00 | deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent. | 30580687 |
| 2018-12-22 11:55:00 | TASK-1 channels displayed strong cardiac expression in mice. Dysregulation of atrial TASK-1 expression in murine atrial fibrillation and heart failure models suggests potential relevance of TASK-1 currents in arrhythmogenesis. | 29881975 |
| 2018-11-10 11:14:00 | studies demonstrate that TASK channels can limit ischemia-reperfusion damage in the cortex, and postconditioning with volatile anesthetics provides neuroprotective actions that depend, in part, on activation of TASK currents in cortical neurons. | 28276488 |
| Type | IDs |
|---|---|
| Synonymous | TASK, Task-1, cTBAK-1 |
| Gene |
UniProtKB-ID:
KCNK3_MOUSE
UniprotKB:
O35111
UniParc:
UPI00000265EA
EMBL:
AF065162,
AF241798,
AF006824,
AB013345,
AB008537,
AF242508
Ensembl:
ENSMUSG00000049265
KO:
mmu:16527
|
| Nucleutide sequences |
EMBL-CDS:
AAG29339.1,
BAA28349.1,
AAF81418.1,
BAA25436.1,
AAC53367.1
Ensembl_TRS:
ENSMUST00000066295
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000098987
RefSeq:
NP_034738.1
|
| Others |
UniRef100:
UniRef100_O35111
UniRef90:
UniRef90_O54912
UniRef50:
UniRef50_O54912
UniGene:
Mm.439936
CCDS:
CCDS19160.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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