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16508 Kcnd2

16508

Kcnd2

potassium voltage-gated channel, Shal-related family, member 2

protein-coding

Mus musculus

基因描述

Type Description
Definition potassium voltage-gated channel, Shal-related family, member 2

研究结论

Date Results Publications
2021-03-13 13:17:00 The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. 32822706
2020-07-25 12:10:00 Study uncovers increased levels of active GSK3beta in the nucleus accumbens (NAc) of mice with a depressive-like phenotype induced by chronic stress. Increased levels of active GSK3beta within the NAc of these mice lead to altered synaptic plasticity in medium spiny neurons through phosphorylation of the Kv4.2 subunit uncovering molecular mechanism of underlying depression-like behaviors. 32209671
2020-07-18 11:39:00 activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex. 32218435
2020-07-18 10:33:00 Results identify the functional interaction between GSK3beta and Kv4.2 channel as a novel mechanism for long-term depression modulation providing exciting insight into the understanding of GSK3beta role in synaptic plasticity. 29790931
2019-08-24 11:29:00 Kv4 interacting dynamically with persistent sodium currents is a key determinant of the irregular firing behaviour of Kiss1(Arc) neurons. 29214635

名称对应

Type IDs
Synonymous AI839615, AW555701, Kv4.2, R75121
Gene
UniProtKB-ID: KCND2_MOUSE
UniprotKB: Q9Z0V2
UniParc: UPI0000025EEC
EMBL: AK032772, BC079667, AB093280, AB045326, AF107780, AK032268
Ensembl: ENSMUSG00000060882
KO: mmu:16508
Nucleutide sequences
EMBL-CDS: AAH79667.1, BAC27787.1, BAC28015.1, BAA97986.1, BAC41464.1, AAD16972.1
Gene_ORFName: MNCb-7013
Ensembl_TRS: ENSMUST00000081542
Protein sequencees
Ensembl_PRO: ENSMUSP00000080257
RefSeq: XP_036021777.1, NP_062671.1
Others
UniRef100: UniRef100_Q9Z0V2
UniRef90: UniRef90_Q63881
UniRef50: UniRef50_Q63881
UniGene: Mm.425316
CCDS: CCDS19934.1

全选

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