| Type | Description |
|---|---|
| Definition | jagged 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:43:00 | Mice with CD11c lineage-specific deletion of Notch ligand gene Dll1, but not Jag2, exhibited accelerated growth of lung and pancreatic tumors concomitant with decreased antigen-specific CD8+T-cell functions and effector-memory (Tem) differentiation. Increased IL-4 but decreased IFN-gamma production and elevated populations of T-regulatory and myeloid-derived suppressor cells were observed in Dll1-ablated mice. | 30940183 |
| 2019-03-02 11:04:00 | these data demonstrate that EC-derived jagged-2 activates Notch2 signaling in HSPCs to promote hematopoietic recovery and has potential as a therapeutic target to accelerate balanced hematopoietic reconstitution after myelosuppression. | 29058691 |
| 2017-06-24 11:23:00 | A deficiency of KLF2 increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha), which led to Th2 amplification. | 27302755 |
| 2015-08-01 11:07:00 | silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma | 25257302 |
| 2015-02-14 10:41:00 | Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. | 24907271 |
| Type | IDs |
|---|---|
| Synonymous | D12Ggc2e, Serh, mJagged2-1, sm |
| Gene |
UniProtKB-ID:
JAG2_MOUSE
UniprotKB:
Q9QYE5
UniParc:
UPI0000192BC0
EMBL:
AF010137,
AF038572,
AC160929,
Y14495
Ensembl:
ENSMUSG00000002799
KO:
mmu:16450
|
| Nucleutide sequences |
EMBL-CDS:
CAA74835.1,
AAF16411.1,
AAC14010.1
Ensembl_TRS:
ENSMUST00000075827
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000075224
RefSeq:
XP_011242301.1,
XP_011242300.1,
XP_006515549.1,
NP_034718.2
|
| Others |
UniRef100:
UniRef100_Q9QYE5
UniRef90:
UniRef90_Q9QYE5
UniRef50:
UniRef50_Q9QYE5
UniGene:
Mm.186146
CCDS:
CCDS26200.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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