| Type | Description |
|---|---|
| Definition | integrin beta 1 binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-05 11:57:00 | ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility. | 28049720 |
| 2013-11-30 12:36:00 | The CCM1 loss resulted in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA-dependent contractility. | 23918940 |
| 2013-09-28 11:24:00 | Data show that phosphorylation of ICAP-1alpha by CaMKII controls beta1 integrin activation and cell adhesion. | 23720740 |
| 2011-10-08 10:36:00 | The ICAP-1 works in concert with kindlin-2 to control the dynamics of beta1 integrin-containing fibrillar adhesions and, thereby, regulates fibronectin deposition and osteoblast mineralization. | 21768292 |
| 2011-03-07 15:45:00 | Live cell imaging, which was performed in both Icap-1-deficient mouse embryonic fibroblasts and cells expressing active beta(1) integrin, shows that the integrin high affinity state favored by talin is antagonistically controlled by ICAP-1. | 18227284 |
| Type | IDs |
|---|---|
| Synonymous | AI449260, AU019480, Icap1 |
| Gene |
UniProtKB-ID:
ITBP1_MOUSE
UniprotKB:
O35671
UniParc:
UPI0000001A5D
EMBL:
AK089937,
AK004172,
AK007635,
BC028772,
AK002786,
AK075577,
AJ001373
Ensembl:
ENSMUSG00000062352
KO:
mmu:16413
|
| Nucleutide sequences |
EMBL-CDS:
AAH28772.1,
BAB23206.1,
BAC35832.1,
BAB22357.1,
BAC41007.1,
BAB25151.1,
CAA04706.1
Ensembl_TRS:
ENSMUST00000173729,
ENSMUST00000232072,
ENSMUST00000076260
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000156312,
ENSMUSP00000134627,
ENSMUSP00000075609
RefSeq:
XP_006515053.1,
NP_001342538.1,
XP_006515052.1,
NP_032429.1,
XP_011242118.1
|
| Others |
UniRef100:
UniRef100_O35671
UniRef90:
UniRef90_O14713
UniRef50:
UniRef50_O14713
UniGene:
Mm.273333
CCDS:
CCDS25833.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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