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1641 DCX

1641

DCX

doublecortin

protein-coding

Homo sapiens

基因描述

Type Description
Definition doublecortin

研究结论

Date Results Publications
2020-06-27 10:35:00 Study shows the DCX E2K mutant protein retains the ability to interact with and bundle microtubules (MT)s, but these MTs show a reduced sensitivity to nocodazole-induced depolymerization as well as slower alpha-tubulin exchange rates. Also shows increased association of DCX E2K mutant with the actin filament (F-ACT) network. 30979500
2020-05-16 11:29:00 this is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of Hirschsprung's disease. 30443988
2019-11-16 11:36:00 Phosphorylation of dublecortin X (DCX) serine 28 (S28) plays a critical role in DCX association with the cytoskeleton in human neuroblastoma cells. 30625347
2019-04-20 11:32:00 Doublecortin can associate with AP-2 without being bound to microtubules. A DCX-G35D mutation causes a dominant-negative dendrite growth phenotype that is not due to a defect in neurofascin endocytosis. 30291144
2019-03-09 10:41:00 exchange rates for the C-terminal truncated DCX protein were resistant to the impact of taxol-induced stabilization 28701724

名称对应

Type IDs
Synonymous DBCN, DC, LISX, SCLH, XLIS
Gene
UniProtKB-ID: DCX_HUMAN, A8K340_HUMAN
UniprotKB: O43602, A8K340
UniParc: UPI000002A7C9, UPI00000012B0, UPI00015DA706
EMBL: AJ005594, AJ005596, AJ003112, AJ005592, AF040254, AL031117, AK290455, AL450490, AF034634, AJ005593, BC027925, CH471120, AF040255, AJ005595, AJ005597
Ensembl: ENSG00000077279
KO: hsa:1641
Nucleutide sequences
EMBL-CDS: CAA06617.1, EAX02643.1, AAH27925.1, AAC31797.1, EAX02647.1, AAC31696.1, EAX02649.1, AAC52037.1, EAX02645.1, CAA05867.1, EAX02644.1, EAX02646.1, EAX02642.1, BAF83144.1
Ensembl_TRS: ENST00000488120, ENST00000358070, ENST00000635795, ENST00000496551, ENST00000371993, ENST00000637453, ENST00000356220, ENST00000636035
Protein sequencees
Ensembl_PRO: ENSP00000419861, ENSP00000350776, ENSP00000361061, ENSP00000490448, ENSP00000489635, ENSP00000490357, ENSP00000348553, ENSP00000490614
RefSeq: NP_001182482.1, NP_835365.1, NP_001356300.1, NP_001356299.1, NP_835366.1, NP_000546.2, XP_011529181.1, NP_001356303.1, NP_001356302.1, NP_835364.1, NP_001356301.1
Others
UniRef100: UniRef100_A8K340, UniRef100_O43602
UniRef90: UniRef90_O43602, UniRef90_O88809
UniRef50: UniRef50_O43602, UniRef50_O88809
UniGene: Hs.34780
CCDS: CCDS14557.1, CCDS14558.1

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