| Type | Description |
|---|---|
| Definition | itchy, E3 ubiquitin protein ligase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:00:00 | Ubiquitination of interleukin-1alpha is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH. | 32587089 |
| 2021-01-02 12:50:00 | Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice. | 32169841 |
| 2020-09-19 16:31:00 | miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH. | 31627713 |
| 2020-06-27 12:15:00 | identified a novel regulatory axis between Itch and Foxo1 in B cells, suggesting that Itch is essential for B-cell development. | 30674954 |
| 2020-06-13 10:47:00 | These results support a novel role for Itch in limiting B cell metabolism and proliferation to suppress antigen-driven B cell responses. | 31311822 |
| Type | IDs |
|---|---|
| Synonymous | 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik |
| Gene |
UniProtKB-ID:
ITCH_MOUSE
UniprotKB:
Q8C863
UniParc:
UPI00001D6A25,
UPI00000E9913
EMBL:
AK048303,
BC062934,
AF037454
Ensembl:
ENSMUSG00000027598
KO:
mmu:16396
|
| Nucleutide sequences |
EMBL-CDS:
AAH62934.1,
BAC33298.1,
AAB99764.1
Ensembl_TRS:
ENSMUST00000109685,
ENSMUST00000029126
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105307,
ENSMUSP00000029126
RefSeq:
NP_032421.2,
NP_001230641.1
|
| Others |
UniRef100:
UniRef100_Q8C863
UniRef90:
UniRef90_Q8C863
UniRef50:
UniRef50_Q8C863
UniGene:
Mm.208286,
Mm.490088
CCDS:
CCDS38293.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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