| Type | Description |
|---|---|
| Definition | DENN domain containing 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 11:57:00 | Variation at DENND1B and Asthma on the Island of Tristan da Cunha. | 31608842 |
| 2017-11-11 13:09:00 | polymorphisms in the DENND1B are significantly associated with development of asthma and atopy and these polymorphisms can influence DENND1B expression and consequently, asthma. | 28668455 |
| 2016-06-04 11:11:00 | Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines. | 26774822 |
| 2016-04-02 12:11:00 | Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3. | 24347560 |
| 2015-10-17 11:36:00 | The guanine nucleotide exchange factor activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt activation downstream of insulin stimulation. | 26055712 |
| Type | IDs |
|---|---|
| Synonymous | C1ORF18, C1orf218, FAM31B |
| Gene |
UniProtKB-ID:
DEN1B_HUMAN,
A0A024R987_HUMAN
UniprotKB:
Q6P3S1,
A0A024R987
UniParc:
UPI0000EE3EAD,
UPI00002046E1,
UPI00015B3BAF,
UPI000178DE4E,
UPI0000227E74,
UPI000046FD8D
EMBL:
BC074735,
AL831839,
AK000061,
BC022561,
AL365258,
CH471067,
AL139136,
BK006960,
AK024832,
BC063877
Ensembl:
ENSG00000213047
KO:
hsa:163486
|
| Nucleutide sequences |
EMBL-CDS:
AAH22561.1,
BAA90918.1,
EAW91281.1,
BAB15024.1,
AAH63877.1,
AAH74735.2,
CAD38548.1,
EAW91280.1,
DAA12502.1,
EAW91285.1,
EAW91284.1,
EAW91283.1
Gene_ORFName:
hCG_2039668
Ensembl_TRS:
ENST00000620048,
ENST00000235453,
ENST00000367396
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000235453,
ENSP00000356366,
ENSP00000479816
RefSeq:
XP_011507549.1,
XP_011507550.1,
XP_011507553.1,
XP_016855959.1,
XP_011507548.1,
NP_001287787.1,
XP_006711256.1,
NP_659414.2,
XP_006711255.1,
NP_001182144.1,
XP_024309395.1,
XP_016855960.1,
NP_001182145.1,
XP_024309394.1,
XP_006711257.1,
XP_005244988.1,
XP_011507551.1
|
| Others |
UniRef100:
UniRef100_Q6P3S1,
UniRef100_A0A024R987
UniRef90:
UniRef90_Q6P3S1
UniRef50:
UniRef50_Q6P3S1
UniGene:
Hs.125056,
Hs.745032
CCDS:
CCDS41452.2,
CCDS72996.1,
CCDS72997.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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