| Type | Description |
|---|---|
| Definition | inositol polyphosphate phosphatase-like 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 10:54:00 | The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP. | 28878342 |
| 2019-05-18 10:48:00 | Here, the authors systematically investigated the bindings of each SAM domain of Eph receptors to the SAM domains from SHIP2 and Odin, and uncover a highly specific SAM-SAM interaction-mediated cytoplasmic Eph-effector binding pattern. | 29749928 |
| 2018-04-07 11:45:00 | Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP. | 28302370 |
| 2017-11-25 13:32:00 | data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced endothelial dysfunction. | 28830894 |
| 2017-11-11 12:13:00 | The authors concluded that the FcgammaRIIb-SHIP2 axis links Abeta neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease. | 27834631 |
| Type | IDs |
|---|---|
| Synonymous | 51C, SHIP2 |
| Gene |
UniProtKB-ID:
SHIP2_MOUSE
UniprotKB:
Q6P549
UniParc:
UPI0000226269
EMBL:
BC049961,
BC063080,
U92477,
BC119453,
AF162781
Ensembl:
ENSMUSG00000032737
KO:
mmu:16332
|
| Nucleutide sequences |
EMBL-CDS:
AAF28187.1,
AAB82337.1,
AAH49961.1,
AAI19454.1,
AAH63080.1
Ensembl_TRS:
ENSMUST00000035836,
ENSMUST00000165052
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000132883,
ENSMUSP00000048057
RefSeq:
NP_001116211.1,
XP_036008593.1,
XP_030098025.1,
XP_011239984.1,
NP_034697.2
|
| Others |
UniRef100:
UniRef100_Q6P549
UniRef90:
UniRef90_O15357-2
UniRef50:
UniRef50_O15357-2
UniGene:
Mm.476000
CCDS:
CCDS21515.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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