| Type | Description |
|---|---|
| Definition | insulin-like growth factor binding protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 13:40:00 | The contrasting effects on tumor establishment and progression of IGFBP-3 expressed by mammary carcinoma cells, compared to systemic stromal and circulating IGFBP-3, highlights the complexity of growth regulation by IGFBP-3 in mammary tumors. | 30419192 |
| 2019-06-01 11:03:00 | Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature. | 30581279 |
| 2019-05-18 12:09:00 | IGFBP-3 inhibits osteoblast differentiation through the BMP-2 signal pathway. | 30454898 |
| 2019-02-02 11:29:00 | The results of this study provide an immune-based mechanism by which host IGFBP3 may promote breast tumor growth in the EO771 murine breast cancer model, and suggest that targeting IGFBP-3 might make a novel contribution to immune therapy for breast cancer. | 29217518 |
| 2018-04-07 10:18:00 | Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells | 28330997 |
| Type | IDs |
|---|---|
| Synonymous | AI649005, IGFBP-3, IGgfbp3 |
| Gene |
UniProtKB-ID:
IBP3_MOUSE,
Q3UR87_MOUSE
UniprotKB:
P47878,
Q3UR87
UniParc:
UPI0000192B41,
UPI00005AC0AA
EMBL:
BC058261,
AK141690,
X81581,
AL607124
Ensembl:
ENSMUSG00000020427
KO:
mmu:16009
|
| Nucleutide sequences |
EMBL-CDS:
AAH58261.1,
CAA57271.1,
BAE24801.1
Ensembl_TRS:
ENSMUST00000020702,
ENSMUST00000135887
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020702,
ENSMUSP00000131670
RefSeq:
XP_011241967.1,
NP_032369.2
|
| Others |
UniRef100:
UniRef100_P47878
UniRef90:
UniRef90_P47878
UniRef50:
UniRef50_P15473
UniGene:
Mm.29254
CCDS:
CCDS24428.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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