| Type | Description |
|---|---|
| Definition | insulin-like growth factor binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:45:00 | Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men. | 32532003 |
| 2020-10-31 13:19:00 | Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease. | 32228319 |
| 2020-07-18 11:42:00 | An integrative systems approach identifies IGFBP-2, Mfap4, and Spp1 as novel candidates in Marfan syndrome-related pathophysiology. | 30677223 |
| 2020-04-04 13:03:00 | Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages. | 31560714 |
| 2018-01-27 10:10:00 | AAV6-mediated IGFBP-2 overexpression in the tibialis anterior (TA) muscles of 4-week-old C57BL/10 and mdx mice reduced the mass of injected muscle after 8weeks, inducing a slower muscle phenotype in C57BL/10 but not mdx mice. Analysis of inflammatory and fibrotic gene expression revealed no changes between control and IGFBP-2 injected muscles in dystrophic (mdx) mice. | 27544574 |
| Type | IDs |
|---|---|
| Synonymous | AI255832, IBP-2, Igfbp-2, mIGFBP-2 |
| Gene |
UniProtKB-ID:
IBP2_MOUSE,
D3YU40_MOUSE
UniprotKB:
P47877,
D3YU40
UniParc:
UPI0000026771,
UPI000161144F
EMBL:
AC121498,
L05437,
L05439,
BC012724,
BC054473,
L05436,
L05438,
CH466548,
AC115870,
X81580
Ensembl:
ENSMUSG00000039323
KO:
mmu:16008
|
| Nucleutide sequences |
EMBL-CDS:
AAH54473.1,
AAB60709.1,
EDL00293.1,
CAA57270.1,
AAH12724.1
Ensembl_TRS:
ENSMUST00000047328,
ENSMUST00000120564
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046610,
ENSMUSP00000112706
RefSeq:
NP_001297588.1,
NP_032368.2,
XP_030106217.1
|
| Others |
UniRef100:
UniRef100_P47877
UniRef90:
UniRef90_P47877
UniRef50:
UniRef50_P18065
UniGene:
Mm.141936
CCDS:
CCDS15036.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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