| Type | Description |
|---|---|
| Definition | NK2 homeobox 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-06 12:34:00 | Studies suggest oncogenic NK2 homeobox 3 homeobox protein (NKX2-3) in lymphomagenesis, and show a mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas. | 27297662 |
| 2017-02-04 10:11:00 | NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts | 27036009 |
| 2015-10-24 10:47:00 | The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD. | 24473197 |
| 2012-09-22 11:17:00 | NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1. | 21968973 |
| 2012-06-16 11:27:00 | A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients. | 22377701 |
| Type | IDs |
|---|---|
| Synonymous | CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3 |
| Gene |
UniProtKB-ID:
NKX23_HUMAN
UniprotKB:
Q8TAU0
UniParc:
UPI00001301E8
EMBL:
BC025788,
AH009193,
AK300856,
AL353719
Ensembl:
ENSG00000119919
KO:
hsa:159296
|
| Nucleutide sequences |
EMBL-CDS:
AAH25788.1,
BAG62506.1,
AAF44651.1
Ensembl_TRS:
ENST00000344586
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000342828
RefSeq:
NP_660328.2,
XP_011537672.1
|
| Others |
UniRef100:
UniRef100_Q8TAU0
UniRef90:
UniRef90_P97334
UniRef50:
UniRef50_P97334
UniGene:
Hs.243272
CCDS:
CCDS41558.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29509190 |
Sci Data Giorgio Giurato , Giovanni Nassa , Annamaria Salvati , Elena Alexandrova , Francesca Rizzo , Tuula A Nyman , Alessandro Weisz , Roberta Tarallo |
2018-03-06 | - |
| 29117863 |
BMC Biol Nila Roy Choudhury , Gregory Heikel , Maryia Trubitsyna , Peter Kubik , Jakub Stanislaw Nowak , Shaun Webb , Sander Granneman , Christos Spanos , Juri Rappsilber , Alfredo Castello , Gracjan Michlewski |
2017-11-08 | - |
| 28473536 |
Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science Yimeng Yin , Ekaterina Morgunova , Arttu Jolma , Eevi Kaasinen , Biswajyoti Sahu , Syed Khund-Sayeed , Pratyush K Das , Teemu Kivioja , Kashyap Dave , Fan Zhong , Kazuhiro R Nitta , Minna Taipale , Alexander Popov , Paul A Ginno , Silvia Domcke , Jian Yan , Dirk Schübeler , Charles Vinson , Jussi Taipale |
2017-05-05 | - |
| 27297662 |
Nat Commun Eloy F Robles , Maria Mena-Varas , Laura Barrio , Sara V Merino-Cortes , Péter Balogh , Ming-Qing Du , Takashi Akasaka , Anton Parker , Sergio Roa , Carlos Panizo , Idoia Martin-Guerrero , Reiner Siebert , Victor Segura , Xabier Agirre , Laura Macri-Pellizeri , Beatriz Aldaz , Amaia Vilas-Zornoza , Shaowei Zhang , Sarah Moody , Maria Jose Calasanz , Thomas Tousseyn , Cyril Broccardo , Pierre Brousset , Elena Campos-Sanchez , Cesar Cobaleda , Isidro Sanchez-Garcia , Jose Luis Fernandez-Luna , Ricardo Garcia-Muñoz , Esther Pena , Beatriz Bellosillo , Antonio Salar , Maria Joao Baptista , Jesús Maria Hernandez-Rivas , Marcos Gonzalez , Maria Jose Terol , Joan Climent , Antonio Ferrandez , Xavier Sagaert , Ari M Melnick , Felipe Prosper , David G Oscier , Yolanda R Carrasco , Martin J S Dyer , Jose A Martinez-Climent |
2016-06-14 | - |
| 27036009 |
Proc Natl Acad Sci U S A Lin-Ting Hsia , Neil Ashley , Djamila Ouaret , Lai Mun Wang , Jennifer Wilding , Walter F Bodmer |
2016-04-12 | - |
| 24737748 |
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Hum. Mol. Genet. Nicola Whiffin , Fay J Hosking , Susan M Farrington , Claire Palles , Sara E Dobbins , Lina Zgaga , Amy Lloyd , Ben Kinnersley , Maggie Gorman , Albert Tenesa , Peter Broderick , Yufei Wang , Ella Barclay , Caroline Hayward , Lynn Martin , Daniel D Buchanan , Aung Ko Win , John Hopper , Mark Jenkins , Noralane M Lindor , Polly A Newcomb , Steve Gallinger , David Conti , Fred Schumacher , Graham Casey , Tao Liu , Swedish Low-Risk Colorectal Cancer Study Group , Harry Campbell , Annika Lindblom , Richard S Houlston , Ian P Tomlinson , Malcolm G Dunlop |
2014-09-01 | - |
| 24473197 |
Sci Rep XiaoCheng Lu , Linjun Tang , Kai Li , JinYu Zheng , Penglai Zhao , Yi Tao , Li-Xin Li |
2014-01-29 | - |
| 23064961 |
GWAS of dental caries patterns in the permanent dentition. J Dent Res J R Shaffer , E Feingold , X Wang , M Lee , K Tcuenco , D E Weeks , R J Weyant , R Crout , D W McNeil , M L Marazita |
2013-01-01 | - |
| 23222517 |
Seventy-five genetic loci influencing the human red blood cell. Nature Pim van der Harst , Weihua Zhang , Irene Mateo Leach , Augusto Rendon , Niek Verweij , Joban Sehmi , Dirk S Paul , Ulrich Elling , Hooman Allayee , Xinzhong Li , Aparna Radhakrishnan , Sian-Tsung Tan , Katrin Voss , Christian X Weichenberger , Cornelis A Albers , Abtehale Al-Hussani , Folkert W Asselbergs , Marina Ciullo , Fabrice Danjou , Christian Dina , Tõnu Esko , David M Evans , Lude Franke , Martin Gögele , Jaana Hartiala , Micha Hersch , Hilma Holm , Jouke-Jan Hottenga , Stavroula Kanoni , Marcus E Kleber , Vasiliki Lagou , Claudia Langenberg , Lorna M Lopez , Leo-Pekka Lyytikäinen , Olle Melander , Federico Murgia , Ilja M Nolte , Paul F O'Reilly , Sandosh Padmanabhan , Afshin Parsa , Nicola Pirastu , Eleonora Porcu , Laura Portas , Inga Prokopenko , Janina S Ried , So-Youn Shin , Clara S Tang , Alexander Teumer , Michela Traglia , Sheila Ulivi , Harm-Jan Westra , Jian Yang , Jing Hua Zhao , Franco Anni , Abdel Abdellaoui , Antony Attwood , Beverley Balkau , Stefania Bandinelli , François Bastardot , Beben Benyamin , Bernhard O Boehm , William O Cookson , Debashish Das , Paul I W de Bakker , Rudolf A de Boer , Eco J C de Geus , Marleen H de Moor , Maria Dimitriou , Francisco S Domingues , Angela Döring , Gunnar Engström , Gudmundur Ingi Eyjolfsson , Luigi Ferrucci , Krista Fischer , Renzo Galanello , Stephen F Garner , Bernd Genser , Quince D Gibson , Giorgia Girotto , Daniel Fannar Gudbjartsson , Sarah E Harris , Anna-Liisa Hartikainen , Claire E Hastie , Bo Hedblad , Thomas Illig , Jennifer Jolley , Mika Kähönen , Ido P Kema , John P Kemp , Liming Liang , Heather Lloyd-Jones , Ruth J F Loos , Stuart Meacham , Sarah E Medland , Christa Meisinger , Yasin Memari , Evelin Mihailov , Kathy Miller , Miriam F Moffatt , Matthias Nauck , Maria Novatchkova , Teresa Nutile , Isleifur Olafsson , Pall T Onundarson , Debora Parracciani , Brenda W Penninx , Lucia Perseu , Antonio Piga , Giorgio Pistis , Anneli Pouta , Ursula Puc , Olli Raitakari , Susan M Ring , Antonietta Robino , Daniela Ruggiero , Aimo Ruokonen , Aude Saint-Pierre , Cinzia Sala , Andres Salumets , Jennifer Sambrook , Hein Schepers , Carsten Oliver Schmidt , Herman H W Silljé , Rob Sladek , Johannes H Smit , John M Starr , Jonathan Stephens , Patrick Sulem , Toshiko Tanaka , Unnur Thorsteinsdottir , Vinicius Tragante , Wiek H van Gilst , L Joost van Pelt , Dirk J van Veldhuisen , Uwe Völker , John B Whitfield , Gonneke Willemsen , Bernhard R Winkelmann , Gerald Wirnsberger , Ale Algra , Francesco Cucca , Adamo Pio d'Adamo , John Danesh , Ian J Deary , Anna F Dominiczak , Paul Elliott , Paolo Fortina , Philippe Froguel , Paolo Gasparini , Andreas Greinacher , Stanley L Hazen , Marjo-Riitta Jarvelin , Kay Tee Khaw , Terho Lehtimäki , Winfried Maerz , Nicholas G Martin , Andres Metspalu , Braxton D Mitchell , Grant W Montgomery , Carmel Moore , Gerjan Navis , Mario Pirastu , Peter P Pramstaller , Ramiro Ramirez-Solis , Eric Schadt , James Scott , Alan R Shuldiner , George Davey Smith , J Gustav Smith , Harold Snieder , Rossella Sorice , Tim D Spector , Kari Stefansson , Michael Stumvoll , W H Wilson Tang , Daniela Toniolo , Anke Tönjes , Peter M Visscher , Peter Vollenweider , Nicholas J Wareham , Bruce H R Wolffenbuttel , Dorret I Boomsma , Jacques S Beckmann , George V Dedoussis , Panos Deloukas , Manuel A Ferreira , Serena Sanna , Manuela Uda , Andrew A Hicks , Josef Martin Penninger , Christian Gieger , Jaspal S Kooner , Willem H Ouwehand , Nicole Soranzo , John C Chambers |
2012-12-20 | - |
| 23128233 |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature Luke Jostins , Stephan Ripke , Rinse K Weersma , Richard H Duerr , Dermot P McGovern , Ken Y Hui , James C Lee , L Philip Schumm , Yashoda Sharma , Carl A Anderson , Jonah Essers , Mitja Mitrovic , Kaida Ning , Isabelle Cleynen , Emilie Theatre , Sarah L Spain , Soumya Raychaudhuri , Philippe Goyette , Zhi Wei , Clara Abraham , Jean-Paul Achkar , Tariq Ahmad , Leila Amininejad , Ashwin N Ananthakrishnan , Vibeke Andersen , Jane M Andrews , Leonard Baidoo , Tobias Balschun , Peter A Bampton , Alain Bitton , Gabrielle Boucher , Stephan Brand , Carsten Büning , Ariella Cohain , Sven Cichon , Mauro D'Amato , Dirk De Jong , Kathy L Devaney , Marla Dubinsky , Cathryn Edwards , David Ellinghaus , Lynnette R Ferguson , Denis Franchimont , Karin Fransen , Richard Gearry , Michel Georges , Christian Gieger , Jürgen Glas , Talin Haritunians , Ailsa Hart , Chris Hawkey , Matija Hedl , Xinli Hu , Tom H Karlsen , Limas Kupcinskas , Subra Kugathasan , Anna Latiano , Debby Laukens , Ian C Lawrance , Charlie W Lees , Edouard Louis , Gillian Mahy , John Mansfield , Angharad R Morgan , Craig Mowat , William Newman , Orazio Palmieri , Cyriel Y Ponsioen , Uros Potocnik , Natalie J Prescott , Miguel Regueiro , Jerome I Rotter , Richard K Russell , Jeremy D Sanderson , Miquel Sans , Jack Satsangi , Stefan Schreiber , Lisa A Simms , Jurgita Sventoraityte , Stephan R Targan , Kent D Taylor , Mark Tremelling , Hein W Verspaget , Martine De Vos , Cisca Wijmenga , David C Wilson , Juliane Winkelmann , Ramnik J Xavier , Sebastian Zeissig , Bin Zhang , Clarence K Zhang , Hongyu Zhao , International IBD Genetics Consortium (IIBDGC) , Mark S Silverberg , Vito Annese , Hakon Hakonarson , Steven R Brant , Graham Radford-Smith , Christopher G Mathew , John D Rioux , Eric E Schadt , Mark J Daly , Andre Franke , Miles Parkes , Severine Vermeire , Jeffrey C Barrett , Judy H Cho |
2012-11-01 | - |
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|---|---|---|
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