| Type | Description |
|---|---|
| Definition | potassium calcium-activated channel subfamily U member 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-10 10:17:00 | results suggest that sperm-specific genes can evolve rapidly and that natural genetic variation may have led to a SLO3 variant that differs from wild type in both pH and intracellular Ca(2+) sensitivities. | 28377504 |
| 2016-02-13 10:57:00 | The authors conclude that Slo3 represents the principal K(+) channel in human sperm that carries the Ca(2+)-activated IKSper current. | 24670955 |
| 2013-02-02 11:57:00 | These results present insights into the function of a protein expected to be critical for human reproduction and provide a framework to study the mechanism of pH gating in SLO3 channels. | 23129643 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3 |
| Gene |
UniProtKB-ID:
KCNU1_HUMAN
UniprotKB:
A8MYU2
UniParc:
UPI0000F079EF
EMBL:
AC124076
Ensembl:
ENSG00000215262
KO:
hsa:157855
|
| Nucleutide sequences |
Ensembl_TRS:
ENST00000399881
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382770
RefSeq:
NP_001027006.2,
XP_011542729.1,
XP_011542726.1,
XP_011542728.1,
XP_024302848.1,
XP_016868633.1
|
| Others |
UniRef100:
UniRef100_A8MYU2
UniRef90:
UniRef90_A8MYU2
UniRef50:
UniRef50_A8MYU2
UniGene:
Hs.13861
CCDS:
CCDS55220.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 28377504 |
A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities. J Biol Chem Yanyan Geng , Juan J Ferreira , Victor Dzikunu , Alice Butler , Pascale Lybaert , Peng Yuan , Karl L Magleby , Lawrence Salkoff , Celia M Santi |
2017-05-26 | - |
| 25675513 |
Proc. Natl. Acad. Sci. U.S.A. Xu-Hui Zeng , Chengtao Yang , Xiao-Ming Xia , Min Liu , Christopher J Lingle |
2015-02-24 |
Kcnu1,
Catsper1,
Lrrc52,
KCNU1
|
| 24670955 |
The Ca2+-activated K+ current of human sperm is mediated by Slo3. Elife Christoph Brenker , Yu Zhou , Astrid Müller , Fabio Andres Echeverry , Christian Trötschel , Ansgar Poetsch , Xiao-Ming Xia , Wolfgang Bönigk , Christopher J Lingle , U Benjamin Kaupp , Timo Strünker |
2014-01-01 |
KCNU1
|
| 23129643 |
Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proc. Natl. Acad. Sci. U.S.A. Manuel D Leonetti , Peng Yuan , Yichun Hsiung , Roderick Mackinnon |
2012-11-20 | - |
| 22747683 |
Genetic variants associated with breast size also influence breast cancer risk. BMC Med. Genet. Nicholas Eriksson , Geoffrey M Benton , Chuong B Do , Amy K Kiefer , Joanna L Mountain , David A Hinds , Uta Francke , Joyce Y Tung |
2012-01-01 |
LOC100128607,
LOC100129646,
GPC6,
LOC101927764,
LOC101929165,
LOC101929710,
ZNF277,
CHEK2,
OSBPL6,
COMTD1,
NEDD1,
RPL23AP37,
MESTP4,
KCNU1,
SPA17P1,
EREG,
ESR1,
FHIT,
ZNF365,
SLC4A1AP,
KAT6B,
SEC14L2,
NPCDR1,
EPGN,
LMOD1,
GCKR,
RBMS3,
GLI2,
A2MP1,
MRPS7P1,
INHBB,
AREG,
SDC4P,
IFITM9P,
RPL19P8,
MIR135A2,
ATP2B4,
CDON,
MTFP1,
ALDH7A1P4,
PTHLH,
EPB41L5,
PTPRG,
CCND1,
LOC642846,
LOC646513,
TTN,
LOC728715,
CLMN,
ZNF703,
TDRD3,
KIRREL3,
ADO,
CADPS,
SERPINA6,
NOL4,
DCLK1,
DOCK4,
SNX17,
ELMO1
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21901158 |
PLoS ONE Marguerite R Irvin , Nathan E Wineinger , Treva K Rice , Nicholas M Pajewski , Edmond K Kabagambe , Charles C Gu , Jim Pankow , Kari E North , Jemma B Wilk , Barry I Freedman , Nora Franceschini , Uli Broeckel , Hemant K Tiwari , Donna K Arnett |
2011-01-01 |
LOC100128714,
GAS1RR,
KCNU1,
SEZ6L,
GAS1,
TRIAP1,
PCBP3,
ATP10A,
ZFAND3,
CSMD1,
CACNA1D,
AP3B1
|
| 20379614 |
Mol. Med. Jed E Rose , Frédérique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl |
2010-03-17 | - |
| 16421571 |
DNA sequence and analysis of human chromosome 8. Nature Chad Nusbaum , Tarjei S Mikkelsen , Michael C Zody , Shuichi Asakawa , Stefan Taudien , Manuel Garber , Chinnappa D Kodira , Mary G Schueler , Atsushi Shimizu , Charles A Whittaker , Jean L Chang , Christina A Cuomo , Ken Dewar , Michael G FitzGerald , Xiaoping Yang , Nicole R Allen , Scott Anderson , Teruyo Asakawa , Karin Blechschmidt , Toby Bloom , Mark L Borowsky , Jonathan Butler , April Cook , Benjamin Corum , Kurt DeArellano , David DeCaprio , Kathleen T Dooley , Lester Dorris , Reinhard Engels , Gernot Glöckner , Nabil Hafez , Daniel S Hagopian , Jennifer L Hall , Sabine K Ishikawa , David B Jaffe , Asha Kamat , Jun Kudoh , Rüdiger Lehmann , Tashi Lokitsang , Pendexter Macdonald , John E Major , Charles D Matthews , Evan Mauceli , Uwe Menzel , Atanas H Mihalev , Shinsei Minoshima , Yuji Murayama , Jerome W Naylor , Robert Nicol , Cindy Nguyen , Sinéad B O'Leary , Keith O'Neill , Stephen C J Parker , Andreas Polley , Christina K Raymond , Kathrin Reichwald , Joseph Rodriguez , Takashi Sasaki , Markus Schilhabel , Roman Siddiqui , Cherylyn L Smith , Tam P Sneddon , Jessica A Talamas , Pema Tenzin , Kerri Topham , Vijay Venkataraman , Gaiping Wen , Satoru Yamazaki , Sarah K Young , Qiandong Zeng , Andrew R Zimmer , Andre Rosenthal , Bruce W Birren , Matthias Platzer , Nobuyoshi Shimizu , Eric S Lander |
2006-01-19 | - |
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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|---|---|---|
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