| Type | Description |
|---|---|
| Definition | PEAK1 related, kinase-activating pseudokinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 12:16:00 | It was discovered that pseudo-kinase pragmin uses the tyrosine kinase CSK to induce protein tyrosine phosphorylation in human cells. | 29503074 |
| 2018-10-06 10:52:00 | analysis of how the kinase fold mediates non-catalytic functions in SgK223 | 29079850 |
| 2017-05-20 14:34:00 | the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. | 27531744 |
| 2017-02-18 11:44:00 | deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis | 27116701 |
| 2016-12-24 10:14:00 | Results provide evidence that NACK was strongly expressed in a subset of non-small cell lung cancer (NSCLCL) samples and interference of NACK inhibits NSCLC progression through failing to activate Notch1 signaling complexes. | 26782286 |
| Type | IDs |
|---|---|
| Synonymous | NACK, PEAK2, PRAGMIN, SGK223 |
| Gene |
UniProtKB-ID:
PRAG1_HUMAN
UniprotKB:
Q86YV5
UniParc:
UPI0003EAF98F
EMBL:
AK122582,
AC068353,
AL833872,
AC103957
Ensembl:
ENSG00000275342
KO:
hsa:157285
|
| Nucleutide sequences |
EMBL-CDS:
CAD38729.1,
BAC56923.1
Ensembl_TRS:
ENST00000615670,
ENST00000622241
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000481109,
ENSP00000479068
RefSeq:
NP_001356688.1,
NP_001074295.2
|
| Others |
UniRef100:
UniRef100_Q86YV5
UniRef90:
UniRef90_Q86YV5
UniRef50:
UniRef50_D3ZMK9
UniGene:
Hs.657673
CCDS:
CCDS43706.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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