| Type | Description |
|---|---|
| Definition | cytochrome P450 family 2 subfamily C member 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:06:00 | CYP3A5*3 and CYP2C8*3 variants influence exposure and clinical outcomes of tacrolimus-based therapy. | 31849280 |
| 2020-03-07 11:21:00 | These results suggest a subset of individuals with genetic variation in CYP2C8 and CYP2C9 recognize that they obtain adequate drug efficacy with lower ibuprofen doses, or take lower doses due to prior side effects. | 30562214 |
| 2020-02-29 11:40:00 | Contrary to previous publications, CYP2C8*3 may confer increased paclitaxel metabolic activity. SLCO1B1 and CYP2C8 genotype may explain some paclitaxel pharmacokinetic variability. | 30520341 |
| 2020-02-08 10:45:00 | There are naturally occurring polymorphisms, CYP2C8*2 and CYP2C8*3, that display altered paclitaxel hydroxylation rates despite these mutations not being located in the active site. Anaerobic stopped-flow measurements determined that these polymorphisms have altered first electron transfer kinetics, compared to CYP2C8*1 (wildtype), that suggest electron transfer from cytochrome P450 reductase (CPR) is disfavored. | 31540428 |
| 2020-01-25 14:32:00 | Not in HLMs or other recombinant CYP2C8 preparations. | 30709838 |
| Type | IDs |
|---|---|
| Synonymous | CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20 |
| Gene |
UniProtKB-ID:
CP2C8_HUMAN,
B7Z1F5_HUMAN
UniprotKB:
P10632,
B7Z1F5
UniParc:
UPI00001F9414,
UPI0001914A86,
UPI0000128256
EMBL:
M21942,
M17398,
AL359672,
AK293328,
CH471066,
X51535,
BC020596,
Y00498,
M17397,
AK292753,
M21941,
AY514490,
AK293327,
AK315823,
X54807
Ensembl:
ENSG00000138115
KO:
hsa:1558
|
| Nucleutide sequences |
EMBL-CDS:
CAA68550.1,
AAA52160.1,
AAA35739.1,
BAH11492.1,
BAF85442.1,
AAA35740.1,
AAH20596.1,
EAW50018.1,
BAF98714.1,
AAA52161.1,
CAA38578.1,
CAA35915.1,
AAR89907.1,
BAH11491.1
Ensembl_TRS:
ENST00000371270,
ENST00000535898,
ENST00000623108,
ENST00000539050
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360317,
ENSP00000445062,
ENSP00000442343,
ENSP00000485110
RefSeq:
NP_001185783.1,
NP_001185782.1,
NP_000761.3,
NP_001185784.1
|
| Others |
UniRef100:
UniRef100_P10632
UniRef90:
UniRef90_P10632
UniRef50:
UniRef50_P10632
UniGene:
Hs.709188
CCDS:
CCDS55721.1,
CCDS7438.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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