| Type | Description |
|---|---|
| Definition | 5-hydroxytryptamine (serotonin) receptor 3A |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:52:00 | Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers. | 33594077 |
| 2020-05-16 12:44:00 | Study performed multiple all-atom molecular dynamics simulations of the mouse homomeric 5-hydroxytryptamine 3A (5-HT3A) serotonin receptor for 15 to 20 mus to observe the dynamic binding and unbinding of 5-hydroxytryptamine (5-HT) (i.e., serotonin) to the binding pocket located on the extracellular domain and allosteric regulation of the transmembrane domain from synergistic 5-HT binding. | 31871207 |
| 2019-10-05 10:28:00 | 5-HT3R signaling may enhance 5-HT release, possibly from EC cells intravascularly, or paracrine, resulting in increases in plasma 5-HT concentration, which in turn, enhances apoptotic activities induced by 5-FU | 30207796 |
| 2019-06-01 10:15:00 | two serotonin-bound cryoelectron microscopy structures of the full-length 5-HT3A receptor in distinct conformations at 3.32 A and 3.89 A resolution that reveal the mechanism underlying channel activation | 30401837 |
| 2019-06-01 10:15:00 | four cryo-electron microscopy structures of the full-length mouse 5-HT3 receptor in complex with the anti-emetic drug tropisetron, with serotonin, and with serotonin and a positive allosteric modulator, at resolutions ranging from 3.2 A to 4.5 A | 30401839 |
| Type | IDs |
|---|---|
| Synonymous | 5-HT3 |
| Gene |
UniProtKB-ID:
5HT3A_MOUSE,
E9QLC0_MOUSE,
Q8K1F4_MOUSE
UniprotKB:
P23979,
E9QLC0,
Q8K1F4
UniParc:
UPI0000026F82,
UPI000002A2DB,
UPI00000E6DC4,
UPI00001779AA
EMBL:
CT009741,
X79283,
BC145743,
Z22772,
X72395,
AF513221,
M74425,
Z22773
Ensembl:
ENSMUSG00000032269
KO:
mmu:15561
|
| Nucleutide sequences |
EMBL-CDS:
CAA55870.1,
CAA51089.1,
CAA55871.1,
AAA37124.1,
CAA80453.1,
AAM47014.1,
AAI45744.1
Ensembl_TRS:
ENSMUST00000003826,
ENSMUST00000217289
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003826,
ENSMUSP00000150647
RefSeq:
NP_001093114.1,
XP_011240700.1,
NP_038589.2
|
| Others |
UniRef100:
UniRef100_P23979,
UniRef100_Q8K1F4,
UniRef100_E9QLC0
UniRef90:
UniRef90_P23979
UniRef50:
UniRef50_P46098
UniGene:
Mm.4831
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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