| Type | Description |
|---|---|
| Definition | vitamin K epoxide reductase complex subunit 1 like 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 11:28:00 | The disputed loop sequence between the 1st and 2d transmembrane domain of VKOR in the cytoplasm. Using molecular dynamics simulations, a T-shaped stacking interaction between warfarin and Tyr 139, within the proposed TY139A warfarin-binding motif, was seen. Y25, A26, and Y139) were essential for warfarin binding to VKOR, with a reversible dynamic warfarin-binding pocket opening and conformational changes . | 29743176 |
| 2019-02-02 10:08:00 | we have established KO HEK 293T cell lines that express either endogenously VKORC1 or VKORC1L1, and found that VKORC1 is more sensitive to OACs than VKORC1L1, whereas rodenticides apparently inhibit both VKOR enzymes equally | 29581108 |
| 2017-11-25 15:47:00 | This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. | 29054760 |
| 2014-05-24 11:17:00 | a concerted action of the four conserved cysteines of VKORC1L1 for active site regeneration | 24532791 |
| 2013-12-07 11:27:00 | The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists. | 23928358 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
VKORL_HUMAN,
A8K0F7_HUMAN
UniprotKB:
Q8N0U8,
A8K0F7
UniParc:
UPI000020E7D2,
UPI0000423DF4,
UPI00015DA4CA
EMBL:
CR627471,
AY423045,
AC093485,
AC073261,
BC027734,
AK289522,
AK304077,
AC093582
Ensembl:
ENSG00000196715
KO:
hsa:154807
|
| Nucleutide sequences |
EMBL-CDS:
CAH10673.1,
BAG64984.1,
AAH27734.2,
AAR82915.1,
BAF82211.1
Ensembl_TRS:
ENST00000648179,
ENST00000360768,
ENST00000434382
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000353998,
ENSP00000497394,
ENSP00000403077
RefSeq:
XP_011514133.1,
NP_775788.2,
NP_001271271.1
|
| Others |
UniRef100:
UniRef100_A8K0F7,
UniRef100_Q8N0U8
UniRef90:
UniRef90_Q8N0U8,
UniRef90_A0A6I8MZ72
UniRef50:
UniRef50_Q6TEK5,
UniRef50_Q8N0U8
UniGene:
Hs.427232
CCDS:
CCDS64663.1,
CCDS5529.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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