| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2 alpha kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:10:00 | Study in eIF2alpha kinase quadruple knockout (4KO) and single eIF2alpha kinase-rescued 4KO mouse embryonic fibroblast cells results indicate that the eIF2alpha kinase HRI is responsible for nanosecond pulsed electric fields (nsPEFs)-induced integrated stress response activation and is activated by nsPEF-generated reactive oxygen species. | 32155190 |
| 2020-03-28 11:28:00 | this study proposes that HRI, eIF2alpha, and HSPB8 define a novel cytosolic unfolded protein response (cUPR) essential for optimal innate immune signaling by large molecular platforms, functionally homologous to the axis of the endoplasmic reticulum UPR. | 31273097 |
| 2019-05-18 12:37:00 | HRI coordinates 2 key translation-regulation pathways, eIF2alphaP and mTORC1, to circumvent ineffective erythropoiesis, highlighting heme and translation in the regulation of erythropoiesis. | 29101239 |
| 2018-09-22 11:36:00 | HRI mediates the cellular confinement and killing of virulent L. monocytogenes. | 29311243 |
| 2018-06-09 10:37:00 | heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2) are sufficient for the integrated stress response; there are no additional eIF2alpha kinases in vertebrates | 27633668 |
| Type | IDs |
|---|---|
| Synonymous | HCR, Hri |
| Gene |
UniProtKB-ID:
E2AK1_MOUSE
UniprotKB:
Q9Z2R9
UniParc:
UPI0000663208
EMBL:
BC111035,
AK032508,
BC028923,
AF028808,
AK020887,
AY033898,
AK173160,
AK014775
Ensembl:
ENSMUSG00000029613
KO:
mmu:15467
|
| Nucleutide sequences |
EMBL-CDS:
AAH28923.1,
AAC79201.1,
BAB32242.1,
AAK55766.1,
BAB29545.1,
AAI11036.1,
BAD32438.1,
BAC27901.1
Ensembl_TRS:
ENSMUST00000100487
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000098056
RefSeq:
NP_038585.2,
XP_017176174.1
|
| Others |
UniRef100:
UniRef100_Q9Z2R9
UniRef90:
UniRef90_Q9Z2R9
UniRef50:
UniRef50_Q9Z2R9
UniGene:
Mm.389709,
Mm.431968
CCDS:
CCDS84994.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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