| Type | Description |
|---|---|
| Definition | hydroxyprostaglandin dehydrogenase 15 (NAD) |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:20:00 | Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity. | 31772225 |
| 2019-03-09 11:07:00 | Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment. | 30250298 |
| 2018-05-26 10:35:00 | down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth. | 28716915 |
| 2017-04-29 11:05:00 | 15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice. | 28423012 |
| 2017-03-18 12:37:00 | the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated. | 27140190 |
| Type | IDs |
|---|---|
| Synonymous | 15-PGDH, AV026552 |
| Gene |
UniProtKB-ID:
PGDH_MOUSE
UniprotKB:
Q8VCC1
UniParc:
UPI000002889D
EMBL:
U44389,
BC021157,
AK146038
Ensembl:
ENSMUSG00000031613
KO:
mmu:15446
|
| Nucleutide sequences |
EMBL-CDS:
AAB41825.1,
AAH21157.1,
BAE26850.1
Ensembl_TRS:
ENSMUST00000034026
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034026
RefSeq:
NP_032304.2
|
| Others |
UniRef100:
UniRef100_Q8VCC1
UniRef90:
UniRef90_O08699
UniRef50:
UniRef50_P15428
UniGene:
Mm.18832
CCDS:
CCDS40341.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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