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15446 Hpgd

15446

Hpgd

hydroxyprostaglandin dehydrogenase 15 (NAD)

protein-coding

Mus musculus

基因描述

Type Description
Definition hydroxyprostaglandin dehydrogenase 15 (NAD)

研究结论

Date Results Publications
2020-11-21 13:20:00 Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity. 31772225
2019-03-09 11:07:00 Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment. 30250298
2018-05-26 10:35:00 down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth. 28716915
2017-04-29 11:05:00 15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice. 28423012
2017-03-18 12:37:00 the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated. 27140190

名称对应

Type IDs
Synonymous 15-PGDH, AV026552
Gene
UniProtKB-ID: PGDH_MOUSE
UniprotKB: Q8VCC1
UniParc: UPI000002889D
EMBL: U44389, BC021157, AK146038
Ensembl: ENSMUSG00000031613
KO: mmu:15446
Nucleutide sequences
EMBL-CDS: AAB41825.1, AAH21157.1, BAE26850.1
Ensembl_TRS: ENSMUST00000034026
Protein sequencees
Ensembl_PRO: ENSMUSP00000034026
RefSeq: NP_032304.2
Others
UniRef100: UniRef100_Q8VCC1
UniRef90: UniRef90_O08699
UniRef50: UniRef50_P15428
UniGene: Mm.18832
CCDS: CCDS40341.1

全选

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