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15445 Hpd

15445

Hpd

4-hydroxyphenylpyruvic acid dioxygenase

protein-coding

Mus musculus

基因描述

Type Description
Definition 4-hydroxyphenylpyruvic acid dioxygenase

研究结论

Date Results Publications
2020-01-11 11:36:00 The findings reveal a previously unknown regulation of 4-hydroxyphenylpyruvic acid dioxygenase (HPD) expression and highlight the physiological significance of TTC36-STK33-PELI1-regulated HPD expression in tyrosinemia and tyrosinemia-associated neurological disorders. 31537781
2019-05-11 10:33:00 We observed long-term postnatal persistence of edited cells in both models, with reduction of plasma PCSK9 and cholesterol levels following in utero Pcsk9 targeting and rescue of the lethal phenotype of hereditary tyrosinemia type 1 following in utero Hpd targeting 30297903
2010-01-21 00:00:00 Gene expressions in tyrosinemia type I model mice with liver failure using microarrays. Numerous genes, including amino acid metabolism and apoptosis related genes, were up- or down-regulated at the onset of liver failure. 16899383

名称对应

Type IDs
Synonymous 4HPPD, Fla, Flp, Hppd, Laf
Gene
UniProtKB-ID: HPPD_MOUSE
UniprotKB: P49429
UniParc: UPI0000029429
EMBL: D29987, AK149416, BC013343, X59530
Ensembl: ENSMUSG00000029445
KO: mmu:15445
Nucleutide sequences
EMBL-CDS: BAA06267.1, CAA42111.1, BAE28861.1, AAH13343.1
Ensembl_TRS: ENSMUST00000031398
Protein sequencees
Ensembl_PRO: ENSMUSP00000031398
RefSeq: NP_032303.1
Others
UniRef100: UniRef100_P49429
UniRef90: UniRef90_P49429
UniRef50: UniRef50_P49429
UniGene: Mm.439709
CCDS: CCDS39265.1

全选

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