| Type | Description |
|---|---|
| Definition | heparanase |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:09:00 | Dichotomic role of heparanase in a murine model of metabolic syndrome. | 33051777 |
| 2020-06-20 11:34:00 | Cytokine induction by chemotherapy was not observed in macrophages isolated from heparanase-knockout mice. Mechanistically, paclitaxel and cisplatin activated methylation of histone H3 on lysine 4 (H3K4) in wild-type but not in heparanase-knockout macrophages. This epigenetic, heparanase-dependent host-response mechanism adds a new perspective to the tumor-promoting functions of chemotherapy. | 31690669 |
| 2020-06-06 13:37:00 | Heparanase is preferentially expressed in experimental obesity-associated breast tumors. Heparanase deficiency abolished obesity-accelerated tumor progression in vivo. Heparanase was required for adipose tissue macrophages to produce inflammatory mediators responsible for local induction of aromatase, a rate-limiting enzyme in estrogen biosynthesis. Estrogen upregulated heparanase in hormone-responsive breast tumors. | 31481501 |
| 2020-03-14 11:18:00 | metastasis has a predilection to organs with low levels of heparanase, TF, TFPI, and TFPI-2 in the microcirculation, which enables tumor cell retention. Heparanase has a role in regulating the microcirculation milieu. | 31128083 |
| 2019-07-20 11:52:00 | HPSE expression increased in mouse livers after carbon tetrachloride (CCl4)-mediated chronic induction of fibrosis, but with a trend to decline during progression of the disease. | 29097791 |
| Type | IDs |
|---|---|
| Synonymous | HSE1, Hpa, Hpr1 |
| Gene |
UniProtKB-ID:
HPSE_MOUSE
UniprotKB:
Q6YGZ1
UniParc:
UPI0000028A14
EMBL:
AK154628,
AF359507,
AY151051,
BC138782,
AK040471,
AY077467,
BC138784
Ensembl:
ENSMUSG00000035273
KO:
mmu:15442
|
| Nucleutide sequences |
EMBL-CDS:
AAI38785.1,
AAQ15188.1,
BAC30600.1,
AAN41636.1,
AAL76083.1,
AAI38783.1,
BAE32725.1
Ensembl_TRS:
ENSMUST00000045617
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000044072
RefSeq:
NP_690016.1
|
| Others |
UniRef100:
UniRef100_Q6YGZ1
UniRef90:
UniRef90_Q6YGZ1
UniRef50:
UniRef50_Q9Y251-2
UniGene:
Mm.265786
CCDS:
CCDS19466.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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