| Type | Description |
|---|---|
| Definition | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:25:00 | To test if Hmgcs2 is important for gonad development in mammals, we pursued two lines of investigations. Firstly, we generated Hmgcs2-null mice using CRISPR/Cas9 and found that these mice had gonads that developed normally even on a sensitized background | 31910233 |
| 2019-09-07 10:58:00 | To elucidate the relationship between HMGCS2 and NF-kB, we tested inhibited and over-expressed NF-kB. We found that NF-kB acted as a positive regulator for HMGCS2 under ketosis treatment conditions. | 31025252 |
| 2017-11-18 10:07:00 | It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 enhances ketogenesis through HMGCS2 signaling activation by p38/NF-kB p65. | 28528772 |
| 2017-10-14 12:09:00 | Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of | 27874312 |
| 2016-05-21 12:45:00 | HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8-/- mice. | 25904331 |
| Type | IDs |
|---|---|
| Synonymous | 1300002P16, mHS |
| Gene |
UniProtKB-ID:
HMCS2_MOUSE
UniprotKB:
P54869
UniParc:
UPI00000E663E
EMBL:
U12790,
BC014714,
AK004902,
U12791,
AK004865,
BC024744
Ensembl:
ENSMUSG00000027875
KO:
mmu:15360
|
| Nucleutide sequences |
EMBL-CDS:
AAH14714.1,
BAB23626.1,
AAH24744.1,
AAA92675.1,
BAB23657.1,
AAA92676.1
Ensembl_TRS:
ENSMUST00000090746,
ENSMUST00000120541
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000088249,
ENSMUSP00000113296
RefSeq:
NP_032282.2
|
| Others |
UniRef100:
UniRef100_P54869
UniRef90:
UniRef90_P22791
UniRef50:
UniRef50_P54868-3
UniGene:
Mm.289131
CCDS:
CCDS17662.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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