| Type | Description |
|---|---|
| Definition | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:28:00 | Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. | 33177714 |
| 2020-07-04 10:10:00 | It was concluded that reducing myeloid HMGCR may be a promising strategy to improve insulin resistance and hepatic steatosis in obesity. | 31690648 |
| 2019-08-10 10:53:00 | Myeloid cell Hmgcr drives atherosclerosis by promoting macrophage migration. | 30354246 |
| 2018-02-24 11:10:00 | Deletion of HMGCR expression in T cells led to a severe decrease in their numbers with the remaining cells displaying an activated phenotype, with an increased proportion of regulatory T cells (Tregs) in particular. | 28542128 |
| 2017-06-10 11:08:00 | These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia. | 28416613 |
| Type | IDs |
|---|---|
| Synonymous | HMG-CoAR, Red |
| Gene |
UniProtKB-ID:
HMDH_MOUSE,
Q8BV96_MOUSE
UniprotKB:
Q01237,
Q8BV96
UniParc:
UPI000024DB3F,
UPI00000EA93C
EMBL:
BC085083,
CH466567,
AK079302,
M62766,
AC154851
Ensembl:
ENSMUSG00000021670
KO:
mmu:15357
|
| Nucleutide sequences |
EMBL-CDS:
EDL00884.1,
AAA37819.1,
AAH85083.1,
BAC37602.1
Ensembl_TRS:
ENSMUST00000022176
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022176
RefSeq:
NP_032281.2,
NP_001347095.1,
XP_036013747.1,
NP_001347094.1
|
| Others |
UniRef100:
UniRef100_Q01237,
UniRef100_Q8BV96
UniRef90:
UniRef90_P51639,
UniRef90_Q8BV96
UniRef50:
UniRef50_Q8BV96,
UniRef50_P04035
UniGene:
Mm.316652
CCDS:
CCDS26706.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员