| Type | Description |
|---|---|
| Definition | cytochrome b5 type A |
| Date | Results | Publications |
|---|---|---|
| 2017-11-04 12:40:00 | A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17. (Review) | 28000554 |
| 2017-08-26 11:07:00 | Data suggest CYP17A1, with electron donor NADPH-P450 reductase, is inherently distributive enzyme but that some processivity is present; some 17alpha-hydroxy pregnenolone formed does not dissociate from CYP17A1 before conversion to dehydroepiandrosterone; CYB5A does not enhance reaction by decreasing k(off) of ligands of CYP17A1. (CYP17A1 = cytochrome P450, family 17, subfamily A, polypeptide 1; CYB5A = cytochrome b5) | 28684414 |
| 2017-08-12 10:42:00 | Data suggest that cytochrome b5 (CYB5) and cytochrome b5 reductase 3 (CYB5R3) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin and myoglobin; the three proteins (CYB5+CYB5R3+CYGB) appear to constitute a metabolon involved in generation of nitric oxide. | 28671819 |
| 2017-06-24 13:00:00 | Thus, although Mn-b5 binds to CYP17A1, it is unable to enhance the lyase reaction, strongly suggesting that cyt b5 has a redox effector role in enhancement of the CYP17A1 mediated lyase reaction necessary for androgen synthesis. | 27297105 |
| 2016-12-17 12:06:00 | This study constructed a model of the membrane-bound full-length human P450 1A2-cyt b5 complex. The model was assembled from several parts using a multiscale modeling approach covering all-atom and coarse-grained molecular dynamics (MD). | 26918755 |
| Type | IDs |
|---|---|
| Synonymous | CYB5, MCB5, METAG |
| Gene |
UniProtKB-ID:
CYB5_HUMAN,
A0A384ME44_HUMAN
UniprotKB:
P00167,
A0A384ME44
UniParc:
UPI0000000DF0,
UPI0000163B44,
UPI000059D5E2
EMBL:
L39941,
BC015182,
M22865,
L39942,
M60174,
CH471117,
CR456990,
L39943,
CA771478,
L39945,
L39792,
L39944,
AC090398,
GQ891327
Ensembl:
ENSG00000166347
KO:
hsa:1528
|
| Nucleutide sequences |
EMBL-CDS:
AAA52165.1,
AAA35729.1,
AAA63169.1,
AAH15182.1,
CAG33271.1,
EAW66544.1,
ADO22189.1
Ensembl_TRS:
ENST00000494131,
ENST00000397914,
ENST00000340533
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000436461,
ENSP00000341625,
ENSP00000381011
RefSeq:
NP_001905.1,
XP_011524137.1,
NP_001177736.1,
NP_683725.1
|
| Others |
UniRef100:
UniRef100_P00167
UniRef90:
UniRef90_P00167
UniRef50:
UniRef50_P00167
UniGene:
Hs.465413
CCDS:
CCDS54188.1,
CCDS12005.1,
CCDS12004.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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